Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA.
Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL, USA.
Cell Immunol. 2018 Aug;330:86-90. doi: 10.1016/j.cellimm.2018.01.005. Epub 2018 Jan 20.
Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.
肺泡巨噬细胞是远端肺实质中最丰富的固有免疫细胞，位于肺泡腔的腔面。它们是最先接触到入侵病原体和污染物的细胞，并帮助启动和解决肺部的免疫反应。与其他组织驻留巨噬细胞类似，肺泡巨噬细胞还具有非免疫、组织特异性的稳态功能，最显著的是清除表面活性剂。在这篇综述中，我们将讨论个体发生和局部肺环境如何塑造肺泡巨噬细胞在健康和疾病中的作用。
