Vargas-Tank L, Wolff C, Castillo T, Carrión Y, Hoppe A, Martínez V, Arman-Merino R
Department of Medicine, San Juan de Dios General Hospital, University of Chile, School of Medicine, Santiago.
Liver. 1988 Feb;8(1):58-62. doi: 10.1111/j.1600-0676.1988.tb00968.x.
It has not yet been established whether serum proline and blood lactate levels are increased in alcoholic liver disease. We measured serum proline and blood lactate in controls and in patients with different stages of alcoholic liver disease in the absence of hepatic failure. Samplings were done in both abstinent and drinking alcoholics. Compared to controls, there was a striking increase in serum proline levels in 52 abstinent alcoholics with little or no hepatic fibrosis by histological assessment (0.10 +/- 0.01 vs. 0.155 +/- 0.008; p less than 0.005). Blood lactate levels were within the normal range and did not correlate with serum proline levels. On the other hand, serum proline and blood lactate levels were independent of hepatic necrosis and inflammation scores. In addition, in 10 patients with blood alcohol concentrations between 0.3 mg/ml and 7.8 mg/ml, serum lactate and proline were significantly elevated (2.42 +/- 0.29 mg/ml and 0.275 +/- 0.0026 mg/ml, respectively; p less than 0.005). These results show that there is an association between serum proline levels and the abstinence period in alcoholic patients. They further suggest that in alcoholic patients neither serum proline nor blood lactate concentrations are reliable markers for liver histological activity (necrosis and inflammation) or fibrosis.
目前尚未确定酒精性肝病患者的血清脯氨酸和血乳酸水平是否升高。我们在无肝衰竭的情况下，测量了对照组以及不同阶段酒精性肝病患者的血清脯氨酸和血乳酸水平。对戒酒者和饮酒者均进行了样本采集。与对照组相比，经组织学评估显示，52例几乎没有或没有肝纤维化的戒酒者血清脯氨酸水平显著升高（0.10±0.01 vs. 0.155±0.008；p<0.005）。血乳酸水平在正常范围内，且与血清脯氨酸水平无关。另一方面，血清脯氨酸和血乳酸水平与肝坏死和炎症评分无关。此外，在10例血酒精浓度介于0.3mg/ml至7.8mg/ml之间的患者中，血清乳酸和脯氨酸显著升高（分别为2.42±0.29mg/ml和0.275±0.0026mg/ml；p<0.005）。这些结果表明，酒精性肝病患者血清脯氨酸水平与戒酒期之间存在关联。它们进一步提示，对于酒精性肝病患者，血清脯氨酸和血乳酸浓度均不是肝脏组织学活性（坏死和炎症）或纤维化的可靠标志物。
