European Commission, Joint Research Centre, Ispra, Italy.
Instituto Gulbenkian de Ciência - Fundação Calouste Gulbenkian, Lisbon, Portugal.
ALTEX. 2021;38(2):351-357. doi: 10.14573/altex.2102221. Epub 2021 Mar 5.
The CIAO project (Modelling the Pathogenesis of COVID-19 using the Adverse Outcome Pathway framework) aims at a holistic assembly of knowledge to deliver a truly transdisciplinary description of the entire COVID-19 physiopathology starting with the initial contact with the SARS-CoV-2 virus and ending with one or several adverse outcomes, e.g., respiratory failure. On 27-28 January 2021, a group of 50+ scientists from numerous organizations around the world met in the 2nd CIAO AOP Design Workshop to discuss the depiction of the COVID-19 disease process as a series of key events (KEs) in a network of AOPs. During the workshop, 74 such KEs forming 13 AOPs were identified, covering COVID-19 manifestations that affect the respiratory, neurological, liver, cardiovascular, kidney and gastrointestinal systems. Modulating factors influencing the course and severity of the disease were also addressed, as was a possible extension of the investigations beyond purely biological phenomena. The workshop ended with the creation of seven working groups, which will further elaborate on the AOPs to be presented and discussed in the 3rd CIAO workshop on 28-29 April 2021.
CIAO 项目（使用不良结局途径框架模拟 COVID-19 的发病机制）旨在全面整合知识，从最初接触 SARS-CoV-2 病毒到出现呼吸衰竭等一个或多个不良结局，对 COVID-19 发病机制进行真正跨学科描述。2021 年 1 月 27-28 日，来自世界各地的 50 多名科学家在 CIAO 第二次 AOP 设计研讨会上齐聚一堂，讨论如何将 COVID-19 疾病过程描绘为 AOP 网络中的一系列关键事件 (KEs)。在研讨会上，确定了 74 个这样的 KEs，形成了 13 个 AOPs，涵盖了影响呼吸系统、神经系统、肝脏、心血管系统、肾脏和胃肠道系统的 COVID-19 表现。还讨论了影响疾病进程和严重程度的调节因素，以及将研究扩展到纯粹的生物学现象之外的可能性。研讨会结束时成立了七个工作组，将进一步详细阐述将在 2021 年 4 月 28-29 日举行的 CIAO 第三次研讨会上提出和讨论的 AOPs。
