Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Drug Deliv Transl Res. 2022 Jan;12(1):124-157. doi: 10.1007/s13346-021-00936-3. Epub 2021 Mar 6.
Curcumin is a biomolecule with functional moieties, which contribute to its anti-inflammatory, anticancer, and antioxidant properties. It has shown several therapeutic effects on treating inflammatory and neurodegenerative diseases and contributes to the reduction of oxidative stress and damage to body tissues. However, its low solubility and fast metabolism limit its absorption in the gastrointestinal (GI) tract and lead to its low bioavailability. Preparation of Pickering emulsions stabilized with mineral or biopolymer-based nanoparticles can be an effective strategy for enhancing the stability of curcumin against degradation, increasing its bioaccessibility in the GI tract, and achieving its controlled release at various locations based on changes in environmental conditions. Various nanoparticles prepared from minerals, proteins, and polysaccharides show potential for stabilizing the curcumin-loaded emulsions, and their wettability can be altered through complexation and formation of hybrid nanoparticles. Stabilization of Pickering emulsions with polysaccharide-based nanoparticles and their complexes can enhance the stability of the curcumin against degradation. Moreover, various protein-based nanoparticles and their conjugated forms with other proteins or polysaccharides can enable the preparation of high internal phase Pickering emulsions (HIPEs) with concomitant higher loading and bioaccessibility of the curcumin molecule. In light of the several therapeutic properties of curcumin, this review article aims to highlight recent studies and the strategies used for the preparation of curcumin Pickering emulsions stabilized by various nanoparticles for enhancing its bioaccessibility during metabolism. These may be useful in pharmaceutical and food industries for drug development and delivery and fortification of food products with this nutraceutical component.
姜黄素是一种具有功能基团的生物分子，这些功能基团使其具有抗炎、抗癌和抗氧化特性。它在治疗炎症和神经退行性疾病方面显示出多种治疗效果，并有助于减少氧化应激和对身体组织的损伤。然而，其低溶解度和快速代谢限制了其在胃肠道（GI）中的吸收，导致其生物利用度低。用基于矿物质或生物聚合物的纳米颗粒稳定的 Pickering 乳液的制备可以是增强姜黄素稳定性、增加其在 GI 道中的生物可及性并根据环境条件的变化实现其在不同部位的控制释放的有效策略。各种由矿物质、蛋白质和多糖制备的纳米颗粒显示出稳定载有姜黄素的乳液的潜力，并且可以通过络合和形成杂化纳米颗粒来改变其润湿性。多糖基纳米颗粒及其复合物稳定 Pickering 乳液可以增强姜黄素的稳定性，防止其降解。此外，各种基于蛋白质的纳米颗粒及其与其他蛋白质或多糖的共轭形式可以制备具有高内部相 Pickering 乳液（HIPE）的载药乳液，同时提高姜黄素分子的载药量和生物可及性。鉴于姜黄素的几种治疗特性，本文旨在强调最近的研究和用于制备由各种纳米颗粒稳定的姜黄素 Pickering 乳液的策略，以提高其在代谢过程中的生物可及性。这些在药物开发和输送以及将这种营养成分强化到食品产品中可能对制药和食品工业有用。
