Research Center in Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University of Cluj-Napoca, 11 Arany Janos Str., RO-400028 Cluj-Napoca, Romania.
Department of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, 47 Gen. Traian Mosoiu Str., RO-400132 Cluj-Napoca, Romania.
Molecules. 2022 Oct 13;27(20):6854. doi: 10.3390/molecules27206854.
Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin). These complexes increase the bioactivity and bioavailability of curcumin. The current review provides these derivatization strategies for curcumin in terms of biological and physico-chemical aspects with a strong focus on different type of proteins, characterization methods, and thermodynamic features of protein-curcumin complexes, and with the aim of evaluating the best performances. The current literature review offers, taking into consideration various biological effects of the CCM, a whole approach for CCM-biomolecules interactions such as CCM-proteins, CCM-nanomaterials, and CCM-natural compounds regarding molecular strategies to improve the bioactivity as well as the bioavailability of curcumin in biological systems.
姜黄素（CCM）是最常被研究的植物化合物之一，具有多种生物学作用，如抗菌、抗病毒、抗真菌、抗肿瘤和抗氧化/抗炎特性。实验室数据和临床试验表明，姜黄素的生物利用度和生物活性受姜黄素分子复合物类型的特征影响。姜黄素具有与蛋白质（如乳清蛋白、牛血清白蛋白、β-乳球蛋白）、碳水化合物、脂质和天然化合物（如白藜芦醇、胡椒碱、槲皮素）形成分子复合物的高能力。这些复合物提高了姜黄素的生物活性和生物利用度。本综述从生物和物理化学方面提供了这些姜黄素的衍生化策略，重点介绍了不同类型的蛋白质、表征方法以及蛋白质-姜黄素复合物的热力学特性，并旨在评估最佳性能。本综述考虑了 CCM 的各种生物学效应，提供了一种关于 CCM-生物分子相互作用的整体方法，例如 CCM-蛋白质、CCM-纳米材料和 CCM-天然化合物，涉及提高姜黄素在生物系统中的生物活性和生物利用度的分子策略。
