Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan 250012, People's Republic of China.
School of Pharmacy, Linyi University, Linyi 27600, People's Republic of China.
J Nat Prod. 2021 Apr 23;84(4):1210-1215. doi: 10.1021/acs.jnatprod.0c01284. Epub 2021 Mar 7.
An investigation of the chemical composition of Chinese liverworts led to the isolation of six new caged clerodane-type diterpenoids, scaparins A-C (-) from and scaparins D-F (-) from . An unknown -trachylobane diterpenoid () and three known terpenoid derivatives (-) were obtained from . The structures of the compounds were established on the basis of physical data (IR, UV, HRESIMS, and 1D and 2D NMR), and the absolute configurations were unequivocally confirmed by comparison of the experimental and calculated electronic circular dichroism spectra. Preliminary bioassays showed that compounds - exhibited moderate to weak quinone reductase-inducing activity in Hepa-1c1c7 cells.
对中国苔类植物的化学成分进行研究，从 中分离得到了 6 个新的笼状 clerodane 型二萜类化合物，scaparins A-C (-)，从 中分离得到了 scaparins D-F (-)。从 中还获得了一个未知的 -trachylobane 二萜类化合物 () 和三个已知的萜类衍生物 (-)。根据物理数据（IR、UV、HRESIMS 和 1D 和 2D NMR）确定了化合物的结构，并通过比较实验和计算的电子圆二色谱谱，明确了绝对构型。初步的生物测定表明，化合物 - 在 Hepa-1c1c7 细胞中表现出中等至弱的醌还原酶诱导活性。
