Your Bright Eye Clinic of Chengdu Hi-tech Zone, Chengdu, Sichuan, China.
Beijing MEM Eye Hospital, Beijing, China.
Eur J Ophthalmol. 2022 Jan;32(1):221-228. doi: 10.1177/1120672121998903. Epub 2021 Mar 7.
To evaluate the effect of low concentration atropine combined with Orthokeratology (OK) lens compared with the OK lens on the changes of axial length in children with moderate and low myopia by meta-analysis.
Databases such as PubMed, Web of Science, Embase, and Cochrane Library were comprehensively searched to collect related studies on atropine combined with the OK lens in the treatment of children with moderate and low myopia. The retrieval time was from the establishment of the database to December 2020. The standardized mean difference (SMD) and its 95% confidence interval (CI) were selected as the effect to analyze the changes of the axial length of the eye axis in children with low and moderate myopia treated with low concentration atropine combined with OK lens.
A total of eight articles were included in this study. Compared with OK lens treatment, low concentration atropine combined with the OK lens significantly slowed down the axial elongation of low and moderate myopia, SMD = -0.68(95% CI: -0.86--0.50, < 0.05). According to the subgroup analysis of treatment time, when the treatment time was less than or equal to 6 months, SMD = -0.63(95% CI: -0.88--0.37, < 0.05), when the treatment time was 1 year, SMD = -0.76(95% CI: -1.08--0.43, < 0.05), and when the treatment time was 2 years, SMD = -0.69(95% CI: -1.07--0.31, < 0.05).
Low concentration atropine combined with the OK lens is more effective than the OK lens in the treatment of children with low to moderate myopia in reducing axial elongation.
通过荟萃分析评估低浓度阿托品联合角膜塑形术（OK 镜）与 OK 镜治疗中低度近视儿童眼轴长度变化的效果。
全面检索 PubMed、Web of Science、Embase 和 Cochrane Library 等数据库，收集关于低浓度阿托品联合 OK 镜治疗中低度近视的相关研究。检索时间从数据库建立到 2020 年 12 月。选择标准化均数差（SMD）及其 95%置信区间（CI）作为效应量，分析低浓度阿托品联合 OK 镜治疗中低度近视儿童眼轴长度的变化。
共纳入 8 篇文章。与 OK 镜治疗相比，低浓度阿托品联合 OK 镜可显著减缓中低度近视的眼轴伸长，SMD=-0.68（95%CI：-0.86--0.50， < 0.05）。根据治疗时间的亚组分析，当治疗时间小于或等于 6 个月时，SMD=-0.63（95%CI：-0.88--0.37， < 0.05），当治疗时间为 1 年时，SMD=-0.76（95%CI：-1.08--0.43， < 0.05），当治疗时间为 2 年时，SMD=-0.69（95%CI：-1.07--0.31， < 0.05）。
与 OK 镜相比，低浓度阿托品联合 OK 镜在减少中低度近视儿童眼轴伸长方面更有效。
