Metal ion levels with use of modular dual mobility constructs: Can the evidence guide us on clinical use?

INTRODUCTION

Dual mobility (DM) use in total hip arthroplasty (THA) has increased, particularly for prevention and management of instability. However, a modular interface raises concern for metal ion generation. The purpose of this study was to determine the 1) serum cobalt and chromium levels; 2) prevalence of ion levels >1 mcg/L; and 3) effect of femoral head material on ion levels following THA using modular DM bearings.

METHODS

We performed a systematic review (MEDLINE, Embase, Cochrane databases) for articles relating to metal ion levels and modular DM (MDM) THA. Eight studies (290 patients) met the inclusion criteria. We recorded post-operative ion levels at a minimum of 12 months, and compared levels with ceramic (n = 125) and metal femoral heads (n = 165). A meta-analysis could not be performed due to poor study quality and heterogeneity.

RESULTS

At average follow-up of 30.4 months, mean cobalt level was 0.71 mcg/L, and mean chromium level was 0.66 mcg/L [22 patients (8%) had elevated ion levels above 1 mcg/L]. When compared to MDM with a ceramic head, metal head use had higher cobalt (1.26 vs. 0.42 mcg/L) and chromium levels (1.23 vs. 0.46 mcg/L). MDM with a metal head was 1.30 times more likely to have elevated ion levels >1 mcg/L. There was no effect of ion levels on outcome scores.

CONCLUSIONS

Measurable elevations of serum cobalt and chromium levels are present in patients with well-functioning MDM THAs. The impact and contributions of the additional metal liner interface are still unclear. The use of a ceramic head appears to mitigate ion release, while reducing other mechanisms of metallosis like taper corrosion. Higher quality studies are necessary to understand whether MDM bearings pose long term issues. Until then, the judicious use of MDM articulations is recommended.