超声化学法以纳米晶 MgAl2O4 为高效催化剂合成 1,2,4,5-四取代咪唑。
Sonochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles using nanocrystalline MgAl2O4 as an effective catalyst.
机构信息
Laboratory of Organic Chemistry Research, Department of Chemistry, Faculty of Chemistry, University of Kashan, P. O. Box 87317-51167, Kashan, Iran.
出版信息
J Adv Res. 2013 Nov;4(6):509-14. doi: 10.1016/j.jare.2012.09.001. Epub 2012 Dec 21.
Abstract
An efficient four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles is described by one-step condensation of an aldehyde, benzil, ammonium acetate and primary aromatic amine with nanocrystalline magnesium aluminate in ethanol under ultrasonic irradiation. High yields, short reaction times, mild conditions, simplicity of operation and easy work-up are some advantages of this protocol.
摘要
描述了一种在超声辐射下，纳米晶氧化铝镁一步缩合醛、联苯、乙酸铵和伯芳胺，高效合成 1,2,4,5-四取代咪唑的方法。该方法具有产率高、反应时间短、条件温和、操作简单、后处理容易等优点。
Zotero 插件