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The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

作者信息

Takle Andrew K, Brown Murray J B, Davies Susannah, Dean David K, Francis Gerraint, Gaiba Alessandra, Hird Alex W, King Frank D, Lovell Peter J, Naylor Antoinette, Reith Alastair D, Steadman Jon G, Wilson David M

机构信息

Department of Medicinal Chemistry, Neurology and GI Centre of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

出版信息

Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. doi: 10.1016/j.bmcl.2005.09.072. Epub 2005 Nov 2.

DOI:10.1016/j.bmcl.2005.09.072
PMID:16260133
Abstract

A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase.

摘要

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