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亲水性磷配体的合成及其在水相金属催化反应中的应用

Synthesis of Hydrophilic Phosphorus Ligands and Their Application in Aqueous-Phase Metal-Catalyzed Reactions.

作者信息

Schlatzer Thomas, Breinbauer Rolf

机构信息

Institute of Organic Chemistry Graz University of Technology Stremayrgasse 9 A-8010 Graz Austria phone.

出版信息

Adv Synth Catal. 2021 Feb 2;363(3):668-687. doi: 10.1002/adsc.202001278. Epub 2020 Dec 30.

DOI:10.1002/adsc.202001278
PMID:33679278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7898532/
Abstract

Transition metal-catalyzed reactions in aqueous media are experiencing a constant increase in interest. In homogenous catalysis the use of water as a solvent offers advantages in cost, safety, the possibility of two-phase catalysis and simplified separation strategies. In the life sciences, transition metal catalysis in aqueous systems enables the ligation or modification of biopolymers in buffer systems or even in their cellular environment. In biocatalysis, aqueous systems allow the simultaneous use of enzymes and transition metal catalysts in cascade reactions. The use of water-soluble phosphine ligands still represents the most reliable and popular strategy for transferring metal catalysts into the aqueous phase. This review summarizes the recent advancements in this field since 2009 and describes current synthetic strategies for the preparation of hydrophilic phosphines and phosphites. In addition, recent applications of transition metal catalysis in aqueous solvents using these hydrophilic ligands are presented.

摘要

水相介质中的过渡金属催化反应正受到越来越多的关注。在均相催化中，使用水作为溶剂在成本、安全性、两相催化的可能性以及简化的分离策略方面具有优势。在生命科学中，水相体系中的过渡金属催化能够在缓冲体系甚至细胞环境中实现生物聚合物的连接或修饰。在生物催化中，水相体系允许在级联反应中同时使用酶和过渡金属催化剂。使用水溶性膦配体仍然是将金属催化剂转移到水相的最可靠和最常用的策略。本综述总结了自2009年以来该领域的最新进展，并描述了目前制备亲水性膦和亚磷酸酯的合成策略。此外，还介绍了使用这些亲水性配体在水相溶剂中进行过渡金属催化的最新应用。

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