Matsumoto Hikaru, Iwai Tomohiro, Sawamura Masaya, Miura Yoshiko
Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, 153-8902, Japan.
Chempluschem. 2024 Oct;89(10):e202400039. doi: 10.1002/cplu.202400039. Epub 2024 Apr 24.
Continuous-flow syntheses using immobilized catalysts can offer efficient chemical processes with easy separation and purification. Porous polymers have gained significant interests for their applications to catalytic systems in the field of organic chemistry. The porous polymers are recognized for their large surface area, high chemical stability, facile modulation of surface chemistry, and cost-effectiveness. It is crucial to immobilize transition-metal catalysts due to their difficult separation and high toxicity. Supported phosphine ligands represent a noteworthy system for the effective immobilization of metal catalysts and modulation of catalytic properties. Researchers have been actively pursuing strategies involving phosphine-metal complexes supported on porous polymers, aiming for high activities, durabilities, selectivities, and applicability to continuous-flow systems. This review provides a concise overview of phosphine-metal complexes supported on porous polymers for continuous-flow catalytic reactions. Polymer catalysts are categorized based on pore sizes, including micro-, meso-, and macroporous polymers. The characteristics of these porous polymers are explored concerning their efficiency in immobilized catalysis and continuous-flow systems.
使用固定化催化剂的连续流合成能够提供具有易于分离和纯化特点的高效化学过程。多孔聚合物因其在有机化学领域催化体系中的应用而备受关注。多孔聚合物因其大表面积、高化学稳定性、表面化学的 facile 调节以及成本效益而被认可。由于过渡金属催化剂分离困难且毒性高，因此固定化过渡金属催化剂至关重要。负载型膦配体是有效固定金属催化剂和调节催化性能的一个值得注意的体系。研究人员一直在积极探索涉及负载在多孔聚合物上的膦 - 金属配合物的策略，旨在实现高活性、耐久性、选择性以及对连续流体系的适用性。本综述简要概述了负载在多孔聚合物上的膦 - 金属配合物用于连续流催化反应的情况。聚合物催化剂根据孔径进行分类，包括微孔、介孔和大孔聚合物。探讨了这些多孔聚合物在固定化催化和连续流体系中的效率方面的特点。
