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金属氧化物纳米颗粒释放的铜离子和钴离子引发皮肤过敏。

Copper and Cobalt Ions Released from Metal Oxide Nanoparticles Trigger Skin Sensitization.

作者信息

Kim Sung-Hyun, Lee Jin Hee, Jung Kikyung, Yang Jun-Young, Shin Hyo-Sook, Lee Jeong Pyo, Jeong Jayoung, Oh Jae-Ho, Lee Jong Kwon

机构信息

Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, South Korea.

出版信息

Front Pharmacol. 2021 Feb 19;12:627781. doi: 10.3389/fphar.2021.627781. eCollection 2021.

DOI:10.3389/fphar.2021.627781
PMID:33679407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7933575/
Abstract

Human skins are exposed to nanomaterials in everyday life from various sources such as nanomaterial-containing cosmetics, air pollutions, and industrial nanomaterials. Nanomaterials comprising metal haptens raises concerns about the skin sensitization to nanomaterials. In this study, we evaluated the skin sensitization of nanomaterials comparing metal haptens and . We selected five metal oxide NPs, containing copper oxide, cobalt monoxide, cobalt oxide, nickel oxide, or titanium oxide, and two types of metal chlorides (CoCl and CuCl), to compare the skin sensitization abilities between NPs and the constituent metals. The materials were applied to KeratinoSens cells for imitated skin-environment setting, and luciferase induction and cytotoxicity were evaluated at 48 h post-incubation. In addition, the response of metal oxide NPs was confirmed in lymph node of BALB/C mice via an method. The results showed that CuO and CoO NPs induce a similar pattern of positive luciferase induction and cytotoxicity compared to the respective metal chlorides; CoO, NiO, and TiO induced no such response. Collectively, the results implied fast-dissolving metal oxide (CuO and CoO) NPs release their metal ion, inducing skin sensitization. However, further investigations are required to elucidate the mechanism underlying NP-induced skin sensitization. Based on ion chelation data, metal ion release was confirmed as the major "factor" for skin sensitization.

摘要

在日常生活中，人类皮肤会通过各种来源接触到纳米材料，如含纳米材料的化妆品、空气污染和工业纳米材料。包含金属半抗原的纳米材料引发了人们对纳米材料皮肤致敏性的担忧。在本研究中，我们比较了金属半抗原和纳米材料的皮肤致敏性。我们选择了五种金属氧化物纳米颗粒，分别含有氧化铜、一氧化钴、氧化钴、氧化镍或氧化钛，以及两种金属氯化物（CoCl和CuCl），以比较纳米颗粒与组成金属之间的皮肤致敏能力。将这些材料应用于KeratinoSens细胞以模拟皮肤环境，并在孵育48小时后评估荧光素酶诱导和细胞毒性。此外，通过一种方法在BALB/C小鼠的淋巴结中证实了金属氧化物纳米颗粒的反应。结果表明，与各自的金属氯化物相比，CuO和CoO纳米颗粒诱导出类似的阳性荧光素酶诱导和细胞毒性模式；CoO、NiO和TiO没有诱导出这种反应。总体而言，结果表明快速溶解的金属氧化物（CuO和CoO）纳米颗粒释放其金属离子，诱导皮肤致敏。然而，需要进一步研究以阐明纳米颗粒诱导皮肤致敏的潜在机制。基于离子螯合数据，金属离子释放被确认为皮肤致敏的主要“因素”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/dd425ee198f9/fphar-12-627781-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/37d1a748da3f/fphar-12-627781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/d11dc0e0cab2/fphar-12-627781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/639e74a76ed1/fphar-12-627781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/92ea9db872d4/fphar-12-627781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/5e7b8c2abbcb/fphar-12-627781-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/dd425ee198f9/fphar-12-627781-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/37d1a748da3f/fphar-12-627781-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/d11dc0e0cab2/fphar-12-627781-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/639e74a76ed1/fphar-12-627781-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/92ea9db872d4/fphar-12-627781-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/5e7b8c2abbcb/fphar-12-627781-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea4/7933575/dd425ee198f9/fphar-12-627781-g007.jpg

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2
Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles.评价金属纳米颗粒经皮肤暴露后的免疫反应和细胞毒性。
Int J Nanomedicine. 2018 Aug 1;13:4445-4459. doi: 10.2147/IJN.S170745. eCollection 2018.
3
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Front Toxicol. 2021 May 28;3:649666. doi: 10.3389/ftox.2021.649666. eCollection 2021.
4
The Research of Toxicity and Sensitization Potential of PEGylated Silver and Gold Nanomaterials.聚乙二醇化银和金纳米材料的毒性及致敏潜力研究
Toxics. 2021 Dec 16;9(12):355. doi: 10.3390/toxics9120355.
5
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Nanomaterials (Basel). 2021 Aug 22;11(8):2140. doi: 10.3390/nano11082140.
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4
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Chem Sci. 2017 Mar 1;8(3):1719-1735. doi: 10.1039/c6sc03631g. Epub 2016 Nov 16.
5
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