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碳基石墨烯纳米片的皮肤致敏性评估

Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets.

作者信息

Kim Sung-Hyun, Hong So-Hye, Lee Jin Hee, Lee Dong Han, Jung Kikyung, Yang Jun-Young, Shin Hyo-Sook, Lee JeongPyo, Jeong Jayoung, Oh Jae-Ho

机构信息

Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju 28159, Korea.

出版信息

Toxics. 2021 Mar 17;9(3):62. doi: 10.3390/toxics9030062.

DOI:10.3390/toxics9030062
PMID:33803047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8002990/
Abstract

Graphene nanoplatelets (GNPs) are one of the major types of carbon based nanomaterials that have different industrial and biomedical applications. There is a risk of exposure to GNP material in individuals involved in their large-scale production and in individuals who use products containing GNPs. Determining the exact toxicity of GNP nanomaterials is a very important agenda. This research aimed to evaluate the skin sensitization potentials induced by GNPs using two types of alternative to animal testing. We analyzed the physicochemical characteristics of the test material by selecting a graphene nanomaterial with a nano-size on one side. Thereafter, we evaluated the skin sensitization effect using an in vitro and an in vivo alternative test method, respectively. As a result, we found that GNPs do not induce skin sensitization. In addition, it was observed that the administration of GNPs did not induce cytotoxicity and skin toxicity. This is the first report of skin sensitization as a result of GNPs obtained using alternative test methods. These results suggest that GNP materials do not cause skin sensitization, and these assays may be useful in evaluating the skin sensitization of some nanomaterials.

摘要

石墨烯纳米片（GNPs）是主要的碳基纳米材料类型之一，具有不同的工业和生物医学应用。参与其大规模生产的个人以及使用含GNPs产品的个人存在接触GNP材料的风险。确定GNP纳米材料的确切毒性是一项非常重要的议程。本研究旨在使用两种动物试验替代方法评估GNPs诱导的皮肤致敏潜力。我们通过选择一侧具有纳米尺寸的石墨烯纳米材料来分析测试材料的物理化学特性。此后，我们分别使用体外和体内替代测试方法评估皮肤致敏效果。结果，我们发现GNPs不会诱导皮肤致敏。此外，观察到给予GNPs不会诱导细胞毒性和皮肤毒性。这是使用替代测试方法获得的关于GNPs导致皮肤致敏的首次报告。这些结果表明GNP材料不会引起皮肤致敏，并且这些检测方法可能有助于评估某些纳米材料的皮肤致敏性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/450005a7d568/toxics-09-00062-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/5c27fb1c7a70/toxics-09-00062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/0b5468e0594d/toxics-09-00062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/15e9c5696ace/toxics-09-00062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/01cb00e93431/toxics-09-00062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/450005a7d568/toxics-09-00062-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/5c27fb1c7a70/toxics-09-00062-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/0b5468e0594d/toxics-09-00062-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/15e9c5696ace/toxics-09-00062-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/01cb00e93431/toxics-09-00062-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ad3/8002990/450005a7d568/toxics-09-00062-g005.jpg

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