Hua Jianian, Jiang Hezi, Wang Hui, Fang Qi
Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Medical College of Soochow University, Suzhou, China.
Front Neurol. 2021 Feb 18;12:635564. doi: 10.3389/fneur.2021.635564. eCollection 2021.
Epidemiological studies have reported inconsistent findings for the association between sleep duration and metabolic syndrome. We aimed to clarify the effects of short and long sleep durations on metabolic syndrome in adults by performing a meta-analysis. Adopting random-effects models, this study analyzed the effects of short and long sleep durations based on data from prospective cohort studies and cross-sectional studies retrieved from four electronic databases from inception to May 2020. We collected data from 235,895 participants included in nine prospective cohort studies and 340,492 participants included in 27 cross-sectional studies. In cohort studies, short sleep duration was associated with an increased risk of metabolic syndrome (RR, 1.15; 95% CI, 1.05-1.25, = 63.1%, < 0.001) compared with normal sleep duration. While long sleep duration was not associated with new-onset metabolic syndrome (RR, 1.02, 0.85-1.18, = 38.0%, = 0.491). In cross-sectional studies, both short (OR, 1.06, 95% CI, 1.01-1.11, = 66.5%, < 0.001) and long (OR, 1.11, 95% CI, 1.04-1.17, = 73.8%, < 0.001) sleep durations were associated with a high prevalence of metabolic syndrome. Only a short sleep duration was associated with an increased risk of metabolic syndrome. Future studies should address whether the association is casual and modifiable.
流行病学研究报告了睡眠时间与代谢综合征之间关联的不一致结果。我们旨在通过进行一项荟萃分析来阐明成人短期和长期睡眠时间对代谢综合征的影响。本研究采用随机效应模型，根据从四个电子数据库检索到的前瞻性队列研究和横断面研究的数据，分析了短期和长期睡眠时间的影响，检索时间从数据库建立至2020年5月。我们收集了9项前瞻性队列研究中的235,895名参与者以及27项横断面研究中的340,492名参与者的数据。在队列研究中，与正常睡眠时间相比，短睡眠时间与代谢综合征风险增加相关（风险比，1.15；95%置信区间，1.05 - 1.25，I² = 63.1%，P < 0.001）。而长睡眠时间与新发代谢综合征无关（风险比，1.02，0.85 - 1.18，I² = 38.0%，P = 0.491）。在横断面研究中，短睡眠时间（比值比，1.06，95%置信区间，1.01 - 1.11，I² = 66.5%，P < 0.001）和长睡眠时间（比值比，1.11，95%置信区间，1.04 - 1.17，I² = 73.8%，P < 0.001）均与代谢综合征的高患病率相关。只有短睡眠时间与代谢综合征风险增加相关。未来的研究应探讨这种关联是否为因果关系以及是否可改变。
