Li Chunmei, Wang Mingshu, Cheng Anchun, Jia Renyong, Yang Qiao, Wu Ying, Zhu Dekang, Zhao Xinxin, Chen Shun, Liu Mafeng, Zhang Shaqiu, Ou Xumin, Mao Sai, Gao Qun, Sun Di, Wen Xingjian, Tian Bin
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Front Microbiol. 2021 Feb 19;12:631523. doi: 10.3389/fmicb.2021.631523. eCollection 2021.
The envelope glycoprotein M (gM), a surface virion component conserved among alphaherpesviruses, is a multiple-transmembrane domain-containing glycoprotein with a complex N-linked oligosaccharide. The gM mediates a diverse range of functions during the viral life cycle. In this review, we summarize the biological features of gM, including its characterization and function in some specicial alphaherpesviruses. gM modulates the virus-induced membrane fusion during virus invasion, transports other proteins to the appropriate intracellular membranes for primary and secondary envelopment during virion assembly, and promotes egress of the virus. The gM can interact with various viral and cellular components, and the focus of recent research has also been on interactions related to gM. And we will discuss how gM participates in the life cycle of alphaherpesviruses.
包膜糖蛋白M（gM）是α疱疹病毒中保守的表面病毒体成分，是一种含有多个跨膜结构域的糖蛋白，具有复杂的N-连接寡糖。gM在病毒生命周期中发挥多种功能。在本综述中，我们总结了gM的生物学特性，包括其在一些特殊α疱疹病毒中的特征和功能。gM在病毒入侵期间调节病毒诱导的膜融合，在病毒体组装过程中将其他蛋白质运输到适当的细胞内膜进行初次和二次包膜，并促进病毒释放。gM可与多种病毒和细胞成分相互作用，近期研究的重点也集中在与gM相关的相互作用上。我们还将讨论gM如何参与α疱疹病毒的生命周期。
