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自闭症小鼠模型中环状RNA的综合表达谱及环状RNA相关ceRNA网络的构建

Comprehensive circRNA Expression Profile and Construction of circRNAs-Related ceRNA Network in a Mouse Model of Autism.

作者信息

Wang Ji, Yang Zhongxiu, Chen Canming, Xu Yang, Wang Hongguang, Liu Bing, Zhang Wei, Jiang Yanan

机构信息

Yangzhou Maternal and Child Health Hospital, Yangzhou, China.

Harbin Children's Hospital, Harbin, China.

出版信息

Front Genet. 2021 Feb 16;11:623584. doi: 10.3389/fgene.2020.623584. eCollection 2020.

DOI:10.3389/fgene.2020.623584
PMID:33679870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7928284/
Abstract

Autism is a common disease that seriously affects the quality of life. The role of circular RNAs (circRNAs) in autism remains largely unexplored. We aimed to detect the circRNA expression profile and construct a circRNA-based competing endogenous RNA (ceRNA) network in autism. Valproate acid was used to establish an model of autism in mice. A total of 1,059 differentially expressed circRNAs (477 upregulated and 582 downregulated) in autism group was identified by RNA sequencing. The expression of novel_circ_015779 and novel_circ_035247 were detected by real-time PCR. A ceRNA network based on altered circRNAs was established, with 9,715 nodes and 150,408 edges. Module analysis was conducted followed by GO and KEGG pathway enrichment analysis. The top three modules were all correlated with autism-related pathways involving "TGF-beta signaling pathway," "Notch signaling pathway," "MAPK signaling pathway," "long term depression," "thyroid hormone signaling pathway," etc. The present study reveals a novel circRNA involved mechanisms in the pathogenesis of autism.

摘要

自闭症是一种严重影响生活质量的常见疾病。环状RNA（circRNA）在自闭症中的作用在很大程度上仍未被探索。我们旨在检测自闭症中circRNA的表达谱，并构建基于circRNA的竞争性内源RNA（ceRNA）网络。使用丙戊酸建立小鼠自闭症模型。通过RNA测序在自闭症组中鉴定出总共1059个差异表达的circRNA（477个上调和582个下调）。通过实时PCR检测了新型_circ_015779和新型_circ_035247的表达。建立了基于改变的circRNA的ceRNA网络，有9715个节点和150408条边。进行了模块分析，随后进行了GO和KEGG通路富集分析。前三个模块均与涉及“TGF-β信号通路”、“Notch信号通路”、“MAPK信号通路”、“长期抑郁”、“甲状腺激素信号通路”等的自闭症相关通路相关。本研究揭示了自闭症发病机制中涉及的一种新型circRNA机制。

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Genome Res. 2020 Mar;30(3):375-391. doi: 10.1101/gr.255463.119. Epub 2020 Mar 3.
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Serum microRNAs in ASD: Association With Monocyte Cytokine Profiles and Mitochondrial Respiration.自闭症谱系障碍中的血清微小RNA：与单核细胞细胞因子谱及线粒体呼吸的关联
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