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ADAM10在胃腺癌中的表达：一项根治性胃切除术队列研究的结果

ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort.

作者信息

Alakus Huseyin, Kaya Mustafa, Ozer Hatice, Egilmez Hatice Reyhan, Karadayi Kursat

机构信息

Huseyin Alakus, MD. Department of Surgical Oncology, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.

Mustafa Kaya, MD. Department of Surgical Oncology, Dr. Ersin Aslan Education & Research Hospital, Gaziantep, Turkey.

出版信息

Pak J Med Sci. 2021 Mar-Apr;37(2):543-549. doi: 10.12669/pjms.37.2.3613.

DOI:10.12669/pjms.37.2.3613
PMID:33679947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7931277/
Abstract

OBJECTIVE

Gastric cancer is among the most common human cancers with high mortality rates. ADAM10, a member of the ADAM (a disintegrin and metalloproteinase) family has also been found to be associated with gastric carcinoma and has been suggested as a potential therapeutic target. Here, we investigated the association of ADAM10 expression with prognosis in gastric adenocarcinoma patients that underwent gastric resection with D2 lymph node dissection.

METHODS

Total 86 consecutive patients that underwent resection for gastric adenocarcinoma were included. Immunohistochemical ADAM10 expression and its association with clinicopathological parameters were analyzed. Univariate and multivariate analyses and survival analyses were performed using SPSS ver.22.

RESULTS

High grade tumors, advanced stage tumors and diffuse type tumors showed significantly worse prognosis. A statistically significant association between ADAM10 expression and overall survival (OS) was observed in the univariate analysis, however, this association did not maintain its significance in the multivariate analysis. No statistically significant association was found ADAM-10 expression and clinicopathological parameters.

CONCLUSION

Immunohistochemical ADAM10 expression may be used as a prognostic marker in gastric adenocarcinoma, however, introduction of a standardized immunohistochemical scoring system seems to be necessary for evaluation of ADAM10 staining.

摘要

目的

胃癌是人类最常见的癌症之一，死亡率很高。ADAM10是ADAM（一种去整合素和金属蛋白酶）家族的成员，也被发现与胃癌有关，并被认为是一个潜在的治疗靶点。在此，我们研究了接受D2淋巴结清扫胃切除术的胃腺癌患者中ADAM10表达与预后的关系。

方法

纳入86例连续接受胃腺癌切除术的患者。分析免疫组化ADAM10表达及其与临床病理参数的关系。使用SPSS 22.0版进行单因素和多因素分析以及生存分析。

结果

高分级肿瘤、晚期肿瘤和弥漫型肿瘤的预后明显较差。单因素分析中观察到ADAM10表达与总生存期（OS）之间存在统计学显著关联，但在多因素分析中这种关联不再具有显著性。未发现ADAM-10表达与临床病理参数之间存在统计学显著关联。

结论

免疫组化ADAM10表达可能用作胃腺癌的预后标志物，然而，引入标准化的免疫组化评分系统似乎对于评估ADAM10染色是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/3e92bbfbc3c8/PJMS-37-543-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/2de574a78972/PJMS-37-543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/0b0234aa79fe/PJMS-37-543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/9138227730ea/PJMS-37-543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/d40d92cb8aac/PJMS-37-543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/d05d7087552c/PJMS-37-543-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/3e92bbfbc3c8/PJMS-37-543-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/2de574a78972/PJMS-37-543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/0b0234aa79fe/PJMS-37-543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/9138227730ea/PJMS-37-543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/d40d92cb8aac/PJMS-37-543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/d05d7087552c/PJMS-37-543-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0c6/7931277/3e92bbfbc3c8/PJMS-37-543-g006.jpg

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