Fang Xinxin, Wen Jing, Sun Mingjun, Yuan Yuan, Xu Qian
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang, China.
Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang City, Liaoning Province, China.
J Cancer. 2019 Oct 15;10(24):6105-6113. doi: 10.7150/jca.32927. eCollection 2019.
Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analysis of the reported results, we find that circRNAs not only participate in the regulation of gastric cancer (GC) cell biological behaviors, such as proliferation, invasion, migration and epithelial mesenchymal transition (EMT), but also are related to the clinicopathological features of GC such as tumor differentiation, TNM stage and metastasis, etc. According to the present screening and verification results, circRNAs are suggested to be used as biomarkers for the early diagnosis and prognosis prediction of GC, and those circRNAs involved in the genesis and development of GC have the potential as novel targets for the individualized treatment of GC.
环状RNA（circRNAs）作为一种组织特异性RNA，其结构比线性RNA更稳定，人们对其与胃癌（GC）的相关性了解甚少。在本综述中，我们概述了circRNAs的合成和特征，并归纳了它们的类别和功能。通过对已报道结果的综合分析，我们发现circRNAs不仅参与胃癌（GC）细胞生物学行为的调控，如增殖、侵袭、迁移和上皮-间质转化（EMT），还与GC的临床病理特征有关，如肿瘤分化、TNM分期和转移等。根据目前的筛选和验证结果，circRNAs有望作为GC早期诊断和预后预测的生物标志物，而那些参与GC发生发展的circRNAs有潜力成为GC个体化治疗的新靶点。
