• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

源自波斯湾海葵的毒液组分具有显著的抗癌活性。

Significant Anticancer Activity of a Venom Fraction Derived from the Persian Gulf Sea Anemone, .

作者信息

Moghadasi Ziba, Shahbazzadeh Delavar, Jamili Shahla, Mosaffa Nariman, Pooshang Bagheri Kamran

机构信息

Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Dept., Biotechnology Research Center, Pasteur Institute of Iran. Tehran, Iran.

Iranian Fisheries Science Research Institute, Agricultural Research, Education and Extension Organizatio,Tehran,Iran.

出版信息

Iran J Pharm Res. 2020 Summer;19(3):402-420. doi: 10.22037/ijpr.2019.14600.12521.

DOI:10.22037/ijpr.2019.14600.12521
PMID:33680040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7758016/
Abstract

Chemotherapy is still one of the main therapeutic regimens in cancer patients but its toxicity is a hard challenge for every patient yet. One of the available solutions is tracing for non-toxic anticancer agents from natural resources. Numerous proteins and peptides in the venom of sea anemones are potentially useful agents with pharmacological properties. Concerning to significance of this issue, the current study was aimed to finding a non-toxic anticancer fraction from the venom of the Persian Gulf sea anemone, . Anticancer and hemolytic activity of crude venom was evaluated and followed by fractionation using RP-HPLC. Breast, Brain, and Colon cancer cell lines were selected to assessment of anticancer activity and toxicity. IC50 of crude venom on the abovementioned cancer cell lines was as 4.13, 6.58, and 31.54 µg, respectively. According to the results obtained by paired sample t-test and comparison of toxicity of the fractions in normal cell line, F10, designated as hadonin, was determined as the candidate anti-cancer fraction. The non-toxic dose of F10 was 20 ng in which showed respectively 66, 29, and 7 anticancer activities on breast, brain, and colon cancer cell lines. According to results, anticancer activity of hadonin is of high pharmaceutical value to follow its therapeutic potency in animal model. In conclusion, the venom of the Persian Gulf sea anemone contains a potential anticancer agent with reasonable activity at nanogram level against three kinds of cancer cells with no toxicity on normal cells.

摘要

化疗仍然是癌症患者的主要治疗方案之一，但其毒性对每个患者来说仍是一项严峻挑战。现有的解决方案之一是从自然资源中寻找无毒抗癌药物。海葵毒液中的许多蛋白质和肽具有潜在的药理活性，可能是有用的药物。鉴于此问题的重要性，本研究旨在从波斯湾海葵毒液中寻找一种无毒抗癌成分。对粗毒液的抗癌和溶血活性进行了评估，随后使用反相高效液相色谱法进行分离。选择乳腺癌、脑癌和结肠癌细胞系评估抗癌活性和毒性。粗毒液对上述癌细胞系的半数抑制浓度（IC50）分别为4.13、6.58和31.54微克。根据配对样本t检验的结果以及各组分在正常细胞系中的毒性比较，确定编号为F10的组分（命名为哈多宁）为候选抗癌组分。F10的无毒剂量为20纳克，对乳腺癌、脑癌和结肠癌细胞系分别显示出66%、29%和7%的抗癌活性。根据结果，哈多宁的抗癌活性具有很高的药用价值，值得在动物模型中进一步研究其治疗效果。总之，波斯湾海葵毒液含有一种潜在的抗癌药物，在纳克水平对三种癌细胞具有合理活性，且对正常细胞无毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/dd9631134102/ijpr-19-402-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/cbbe27b4ba8d/ijpr-19-402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/b08c73972da7/ijpr-19-402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/938edd438424/ijpr-19-402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/59a5d828e643/ijpr-19-402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/440d5c58a027/ijpr-19-402-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/ba7fd2010855/ijpr-19-402-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/309d8e86c9bd/ijpr-19-402-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/5e849e709867/ijpr-19-402-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/a93214b04201/ijpr-19-402-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/5f08b61fad8a/ijpr-19-402-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bf278fffaf0a/ijpr-19-402-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/286f09221de2/ijpr-19-402-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bfc66c9f4b49/ijpr-19-402-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/4473d7c4b1d4/ijpr-19-402-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/4bbbdf4fb2a8/ijpr-19-402-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bb8b2b5076da/ijpr-19-402-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/dd9631134102/ijpr-19-402-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/cbbe27b4ba8d/ijpr-19-402-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/b08c73972da7/ijpr-19-402-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/938edd438424/ijpr-19-402-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/59a5d828e643/ijpr-19-402-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/440d5c58a027/ijpr-19-402-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/ba7fd2010855/ijpr-19-402-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/309d8e86c9bd/ijpr-19-402-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/5e849e709867/ijpr-19-402-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/a93214b04201/ijpr-19-402-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/5f08b61fad8a/ijpr-19-402-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bf278fffaf0a/ijpr-19-402-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/286f09221de2/ijpr-19-402-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bfc66c9f4b49/ijpr-19-402-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/4473d7c4b1d4/ijpr-19-402-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/4bbbdf4fb2a8/ijpr-19-402-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/bb8b2b5076da/ijpr-19-402-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc5/7758016/dd9631134102/ijpr-19-402-g017.jpg

相似文献

1
Significant Anticancer Activity of a Venom Fraction Derived from the Persian Gulf Sea Anemone, .源自波斯湾海葵的毒液组分具有显著的抗癌活性。
Iran J Pharm Res. 2020 Summer;19(3):402-420. doi: 10.22037/ijpr.2019.14600.12521.
2
Toxicity and Potential Pharmacological Activities in the Persian Gulf Venomous Sea Anemone, .波斯湾有毒海葵的毒性及潜在药理活性
Iran J Pharm Res. 2018 Summer;17(3):940-955.
3
Revisiting venom of the sea anemone Stichodactyla haddoni: Omics techniques reveal the complete toxin arsenal of a well-studied sea anemone genus.重新审视海葵石房蛤毒素：组学技术揭示了一种研究充分的海葵属的完整毒素库。
J Proteomics. 2017 Aug 23;166:83-92. doi: 10.1016/j.jprot.2017.07.007. Epub 2017 Jul 21.
4
The Mitochondrial Genome of the Sea Anemone Reveals Catalytic Introns, Insertion-Like Element, and Unexpected Phylogeny.海葵的线粒体基因组揭示了催化内含子、类插入元件及意外的系统发育关系。
Life (Basel). 2021 Apr 28;11(5):402. doi: 10.3390/life11050402.
5
Physiological responses of the symbiotic shrimp Ancylocaris brevicarpalis and its host sea anemone Stichodactyla haddoni to ocean acidification.共生虾Ancylocaris brevicarpalis 和其宿主海葵Stichodactyla haddoni 对海洋酸化的生理响应。
Mar Pollut Bull. 2022 Feb;175:113287. doi: 10.1016/j.marpolbul.2021.113287. Epub 2022 Feb 1.
6
Biological activity of sea anemone proteins: II. Cytolysis and cell line toxicity.海葵蛋白的生物活性：II. 细胞溶解及细胞系毒性
Indian J Exp Biol. 2010 Dec;48(12):1233-6.
7
Pharmacological and biomedical properties of sea anemones Paracondactylis indicus, Paracondactylis sinensis, Heteractis magnifica and Stichodactyla haddoni from East coast of India.印度东海岸海葵 Paracondactylis indicus、Paracondactylis sinensis、Heteractis magnifica 和 Stichodactyla haddoni 的药理学和生物医学特性。
Asian Pac J Trop Med. 2011 Sep;4(9):722-6. doi: 10.1016/S1995-7645(11)60181-8.
8
Novel peptide toxins from the sea anemone Stichodactyla haddoni.来自哈氏柄海葵的新型肽毒素。
Peptides. 2008 Apr;29(4):536-44. doi: 10.1016/j.peptides.2007.12.010. Epub 2008 Feb 19.
9
Antimicrobial activity of tissue and associated bacteria from benthic sea anemone Stichodactyla haddoni against microbial pathogens.来自底栖海葵哈氏刺胞海葵的组织及其相关细菌对微生物病原体的抗菌活性。
J Environ Biol. 2007 Oct;28(4):789-93.
10
The first report on coagulation and phospholipase A2 activities of Persian Gulf lionfish, Pterois russelli, an Iranian venomous fish.关于伊朗有毒鱼类波斯湾狮子鱼（细纹狮子鱼）凝血和磷脂酶A2活性的首次报告。
Toxicon. 2016 Apr;113:25-31. doi: 10.1016/j.toxicon.2016.02.004. Epub 2016 Feb 4.

引用本文的文献

1
Toxicity Mechanism of Dangerous Scorpion Stings in Iran.伊朗危险蝎子蜇伤的毒性机制
J Arthropod Borne Dis. 2023 Jun 30;17(2):105-119. doi: 10.18502/jad.v17i2.13616. eCollection 2023 Jun.
2
Discovery of a New Analgesic Peptide, Leptucin, from the Iranian Scorpion, .从伊朗蝎子中发现一种新型阿片样肽 Leptucin
Molecules. 2021 Apr 28;26(9):2580. doi: 10.3390/molecules26092580.

本文引用的文献

1
Exploring the ocean for new drug developments: Marine pharmacology.探索海洋以开发新药：海洋药理学。
J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):83-91. doi: 10.4103/0975-7406.171700.
2
The first report on coagulation and phospholipase A2 activities of Persian Gulf lionfish, Pterois russelli, an Iranian venomous fish.关于伊朗有毒鱼类波斯湾狮子鱼（细纹狮子鱼）凝血和磷脂酶A2活性的首次报告。
Toxicon. 2016 Apr;113:25-31. doi: 10.1016/j.toxicon.2016.02.004. Epub 2016 Feb 4.
3
Recent Advances in Drug Discovery from South African Marine Invertebrates.
南非海洋无脊椎动物药物发现的最新进展
Mar Drugs. 2015 Oct 14;13(10):6366-83. doi: 10.3390/md13106366.
4
Marine Peptides: Bioactivities and Applications.海洋肽：生物活性与应用
Mar Drugs. 2015 Jun 29;13(7):4006-43. doi: 10.3390/md13074006.
5
Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012.对1985年至2012年这28年间发现的新型海洋天然产物生物活性的统计研究。
Mar Drugs. 2015 Jan 7;13(1):202-21. doi: 10.3390/md13010202.
6
Toxins and drug discovery.毒素与药物发现
Toxicon. 2014 Dec 15;92:193-200. doi: 10.1016/j.toxicon.2014.10.020. Epub 2014 Oct 29.
7
Antibody-drug conjugates: an emerging modality for the treatment of cancer.抗体偶联药物：一种用于癌症治疗的新兴模式。
Ann N Y Acad Sci. 2014 Aug;1321:41-54. doi: 10.1111/nyas.12499.
8
Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells.加勒比海葵 Bunodeopsis globulifera 中的毒素增加顺铂诱导的肺腺癌细胞的细胞毒性。
J Venom Anim Toxins Incl Trop Dis. 2013 May 7;19(1):12. doi: 10.1186/1678-9199-19-12.
9
Cytotoxic and cytolytic cnidarian venoms. A review on health implications and possible therapeutic applications.细胞毒性和细胞溶解的刺胞动物毒液。对健康影响和可能的治疗应用的综述。
Toxins (Basel). 2013 Dec 27;6(1):108-51. doi: 10.3390/toxins6010108.
10
A historical perspective on the development of the cytarabine (7days) and daunorubicin (3days) treatment regimen for acute myelogenous leukemia: 2013 the 40th anniversary of 7+3.阿糖胞苷（7 天）联合柔红霉素（3 天）方案治疗急性髓细胞白血病的历史回顾：2013 年是 7+3 方案的第 40 个年头。
Blood Cells Mol Dis. 2013 Feb;50(2):119-30. doi: 10.1016/j.bcmd.2012.10.005. Epub 2012 Nov 12.