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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):93-7. doi: 10.1007/BF00169483.

The effect of the K+ channel agonist BRL 34915 on membrane conductance was investigated in isolated guinea-pig cardiac myocytes. 2. BRL 34915 reduced the duration of the transmembrane action potential and slightly increased the membrane resting potential in a concentration-dependent manner. 3. BRL 34915 removed the rectification in the steady-state current-voltage relationship. At membrane potentials more negative than the K+ equilibrium potential, membrane conductance was reduced. In the presence of 10(-4) mol/l BRL 34915, the current-voltage relationship was linear, i.e. of an ohmic type. 4. The BRL 34915-mediated change in membrane conductance was susceptible to the K+ channel blockers BaCl2 and tetrahydroaminoacridine. 5. In conclusion, BRL 34915 modifies K+ conductance in the cardiac cell membrane. The precise nature of the K+ conductance change remains to be elucidated.

在分离的豚鼠心肌细胞中研究了钾通道激动剂BRL 34915对膜电导的影响。2. BRL 34915以浓度依赖性方式缩短跨膜动作电位的持续时间，并轻微增加膜静息电位。3. BRL 34915消除了稳态电流-电压关系中的整流作用。在膜电位比钾平衡电位更负时，膜电导降低。在存在10(-4)mol/L BRL 34915的情况下，电流-电压关系呈线性，即欧姆型。4. BRL 34915介导的膜电导变化对钾通道阻滞剂氯化钡和四氢氨基吖啶敏感。5. 总之，BRL 34915改变心肌细胞膜中的钾电导。钾电导变化的确切性质仍有待阐明。

Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):93-7. doi: 10.1007/BF00169483.

The effect of the K+ channel agonist BRL 34915 on membrane conductance was investigated in isolated guinea-pig cardiac myocytes. 2. BRL 34915 reduced the duration of the transmembrane action potential and slightly increased the membrane resting potential in a concentration-dependent manner. 3. BRL 34915 removed the rectification in the steady-state current-voltage relationship. At membrane potentials more negative than the K+ equilibrium potential, membrane conductance was reduced. In the presence of 10(-4) mol/l BRL 34915, the current-voltage relationship was linear, i.e. of an ohmic type. 4. The BRL 34915-mediated change in membrane conductance was susceptible to the K+ channel blockers BaCl2 and tetrahydroaminoacridine. 5. In conclusion, BRL 34915 modifies K+ conductance in the cardiac cell membrane. The precise nature of the K+ conductance change remains to be elucidated.

在分离的豚鼠心肌细胞中研究了钾通道激动剂BRL 34915对膜电导的影响。2. BRL 34915以浓度依赖性方式缩短跨膜动作电位的持续时间，并轻微增加膜静息电位。3. BRL 34915消除了稳态电流-电压关系中的整流作用。在膜电位比钾平衡电位更负时，膜电导降低。在存在10(-4)mol/L BRL 34915的情况下，电流-电压关系呈线性，即欧姆型。4. BRL 34915介导的膜电导变化对钾通道阻滞剂氯化钡和四氢氨基吖啶敏感。5. 总之，BRL 34915改变心肌细胞膜中的钾电导。钾电导变化的确切性质仍有待阐明。