Eisner D A, Vaughan-Jones R D
Cell Calcium. 1983 Dec;4(5-6):371-86. doi: 10.1016/0143-4160(83)90015-5.
Changes of intracellular Ca concentration in cardiac muscle have significant effects on transmembrane currents and many of these effects can be accounted for by postulating the existence of Ca-activated K channels in the heart. However, the evidence that such channels exist is equivocal. This is partly because of technical problems, for example the difficulty of identifying an individual ionic current amongst the many currents that exist in the heart. An additional problem, however, is posed by the fact that other currents may also be modulated by Ca ions. It is important therefore to distinguish between these currents and those caused by Ca-activated, K-specific channels. In this review we consider the evidence for Ca activated currents in the heart and, in particular, we discuss whether or not these currents are carried exclusively by K ions.
心肌细胞内钙离子浓度的变化对跨膜电流有显著影响，其中许多影响可以通过假设心脏中存在钙激活钾通道来解释。然而，此类通道存在的证据并不明确。部分原因是技术问题，例如在心脏中存在的众多电流中识别单个离子电流存在困难。然而，另一个问题是其他电流也可能受到钙离子的调节。因此，区分这些电流与由钙激活的钾特异性通道引起的电流非常重要。在这篇综述中，我们考虑了心脏中钙激活电流的证据，特别是讨论了这些电流是否仅由钾离子携带。
