精神药物与α-1酸性糖蛋白变体结合的选择性。
Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
作者信息
Eap C B, Cuendet C, Baumann P
机构信息
Clinique Psychiatrique Universitaire de Lausanne, Hôpital de Cery, Prilly, Switzerland.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337(2):220-4. doi: 10.1007/BF00169251.
The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
已通过使用固定化电解质的等电聚焦从市售α-1酸性糖蛋白（AAG）中分离出其S型和F型变体。在使用多隔室系统的平衡透析实验中，与F-AAG相比，发现S-AAG对各种碱性药物具有更高的亲和力：阿米替林、去甲替林、丙咪嗪、地昔帕明、曲米帕明、美沙酮、硫利达嗪、氯米帕明、去甲氯米帕明和马普替林。美沙酮的选择性（与S-AAG和F-AAG的结合）最为明显，硫利达嗪的选择性最低，而酸性药物美芬妥英则不存在这种选择性。
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