Liu Jinlin, Zhong Li, Guo Rui
College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China.
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, California, USA.
Oxid Med Cell Longev. 2021 Feb 18;2021:6635836. doi: 10.1155/2021/6635836. eCollection 2021.
Cardiovascular disease (CVD) is the leading cause of death in the world. The mechanism behind CVDs has been studied for decades; however, the pathogenesis is still controversial. Mitochondrial homeostasis plays an essential role in maintaining the normal function of the cardiovascular system. The alterations of any protein function in mitochondria may induce abnormal mitochondrial quality control and unexpected mitochondrial dysfunction, leading to CVDs. Posttranslational modifications (PTMs) affect protein function by reversibly changing their conformation. This review summarizes how common and novel PTMs influence the development of CVDs by regulating mitochondrial quality control. It provides not only ideas for future research on the mechanism of some types of CVDs but also ideas for CVD treatments with therapeutic potential.
心血管疾病（CVD）是全球主要的死亡原因。几十年来一直在研究心血管疾病背后的机制；然而，其发病机制仍存在争议。线粒体稳态在维持心血管系统的正常功能中起着至关重要的作用。线粒体中任何蛋白质功能的改变都可能导致线粒体质量控制异常和意外的线粒体功能障碍，从而引发心血管疾病。翻译后修饰（PTM）通过可逆地改变蛋白质构象来影响其功能。本综述总结了常见和新型的翻译后修饰如何通过调节线粒体质量控制来影响心血管疾病的发展。它不仅为未来研究某些类型心血管疾病的机制提供了思路，也为具有治疗潜力的心血管疾病治疗提供了思路。
