成釉细胞瘤中的表观遗传改变：文献综述。
Epigenetic alterations in ameloblastomas: A literature review.
作者信息
Santos Erison-Santana, Rodrigues-Fernandes Carla-Isabelly, Cabral Joab-Cabral, Fonseca Felipe-Paiva, Leme Adriana-Franco-Paes
机构信息
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
J Clin Exp Dent. 2021 Mar 1;13(3):e295-e302. doi: 10.4317/jced.56191. eCollection 2021 Mar.
BACKGROUND
Ameloblastoma is a locally aggressive tumor, originated from odontogenic epithelium, and affects the jawbones with an elevated recurrence rate. The molecular mechanisms involved with the pathogenesis of this tumor remain undetermined. This review aimed to describe the current data regarding epigenetic alterations in ameloblastoma.
MATERIAL AND METHODS
A systematized electronic search was performed in the English-language literature in three databases, combining the following keywords: ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation.
RESULTS
According to the gathered results of 11 studies in this review, epigenetic alterations could induce the development and progression of ameloblastoma. DNA methylation has been the most assessed mechanism in ameloblastomas.
CONCLUSIONS
Current literature data indicate that epigenetic events can be involved in the etiopathogenesis of ameloblastomas. Ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation.
背景
成釉细胞瘤是一种具有局部侵袭性的肿瘤，起源于牙源性上皮，可累及颌骨，复发率较高。该肿瘤发病机制所涉及的分子机制尚未明确。本综述旨在描述有关成釉细胞瘤表观遗传改变的现有数据。
材料与方法
在三个数据库中对英文文献进行系统的电子检索，组合以下关键词：成釉细胞瘤、表观遗传学、甲基化、非编码RNA、组蛋白乙酰化。
结果
根据本综述中11项研究的汇总结果，表观遗传改变可诱导成釉细胞瘤的发生和发展。DNA甲基化是成釉细胞瘤中研究最多的机制。
结论
当前文献数据表明，表观遗传事件可能参与成釉细胞瘤的发病机制。成釉细胞瘤、表观遗传学、甲基化、非编码RNA、组蛋白乙酰化。
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