Shulkes A, Harris Q L, Lewis S J, Vajda J E, Jarrott B
University of Melbourne, Department of Surgery, Australia.
Neuropeptides. 1988 Feb-Mar;11(2):77-81. doi: 10.1016/0143-4179(88)90014-5.
There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study compared the short term (24 hr) and long term (3 wk) effects of amygdaloid kindled seizures, and the short term effects of non-kindled seizures (cortical suprathreshold stimulation-induced seizures, STS), on the concentrations of NT in 13 brain regions in the rat. Whereas kindled seizures produced neither short term nor long term changes in NT, the STS resulted in altered NT concentrations, with a decrease in the cortex and increases in the hippocampus and cervical spinal cord. These results reveal seizure-type specific changes in NT in 3 brain regions; and indicate that although NT does not appear to be involved in kindling, it may be important in the neurochemical mechanisms underlying STS.
现在有大量证据表明，假定的神经肽参与了致痫过程。神经降压素（NT）可影响中枢神经系统许多部位的神经元兴奋性，可能与点燃现象相关，但此前尚未在癫痫点燃模型中进行研究。本研究比较了杏仁核点燃癫痫发作的短期（24小时）和长期（3周）效应，以及非点燃癫痫发作（皮层阈上刺激诱发癫痫发作，STS）对大鼠13个脑区NT浓度的短期影响。虽然点燃癫痫发作对NT既没有短期影响也没有长期影响，但STS导致NT浓度发生改变，皮层中NT浓度降低，海马体和颈脊髓中NT浓度升高。这些结果揭示了3个脑区中NT的癫痫发作类型特异性变化；并表明，虽然NT似乎不参与点燃过程，但它可能在STS潜在的神经化学机制中起重要作用。
