Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, USA.
J Neuroinflammation. 2011 Nov 30;8:168. doi: 10.1186/1742-2094-8-168.
Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.
许多自闭症谱系疾病（ASD）患儿存在癫痫发作活动，但发病机制尚不清楚。最近的证据表明，神经炎症可能与癫痫发作有关。我们假设，由于过敏、环境和/或应激触发因素导致的大脑肥大细胞激活可能导致血脑屏障的局灶性破坏和神经炎症，从而导致癫痫发作。当抗癫痫药物无效时，治疗神经炎症可能是有用的。
