Ghasemi Elahe, Ferdosi-Shahandashti Elaheh, Rajabnia Mehdi, Sabbagh Parisa, Maali Amirhosein, Ferdosi-Shahandashti Azadeh
Department of Biotechnology, Islamic Azad University, Damghan, Iran.
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Caspian J Intern Med. 2021 Winter;12(1):65-69. doi: 10.22088/cjim.12.1.65.
Multidrug resistance (MDR) in has created therapeutic challenges all over the world. The present study was conducted for evaluating the prevalence of class I integron, determining the gene cassettes and antimicrobial resistance profile of isolates from clinical samples in Babol, North of Iran.
During a 13-month period, 30 isolates were collected from Ayatollah Rouhani Hospital, Babol, Iran. Various types of antimicrobial agents were used to determine the resistance pattern. Class I integron and associated gene cassettes were detected by PCR assay.
The resistance rates to AP, CPM, CTX, TM, NI, IMI, AK, CIP and GM antimicrobials were 100%, 93.3%, 33.3%, 33.3%, 30%, 20%, 20%, 20% and 13.3%, respectively. The distribution results of genes showed that 63.3% of isolates carried the genes. Also, the prevalence of , , and genes were estimated at 36.6%%, 33.3%, 6.6% and 0%, respectively.
Our results showed that class I integrons have a widespread distribution among the isolates and have clinical relevance to MDR isolates. The results confirmed the necessity for uninterrupted monitoring to prevent distribution of multidrug resistance among . strains in Iran.
[细菌名称未给出]中的多重耐药性（MDR）在全球范围内带来了治疗挑战。本研究旨在评估I类整合子的流行情况，确定伊朗北部巴博尔临床样本中[细菌名称未给出]分离株的基因盒及抗菌药物耐药谱。
在13个月的时间里，从伊朗巴博尔的阿亚图拉·鲁哈尼医院收集了30株[细菌名称未给出]分离株。使用各种类型的抗菌药物来确定耐药模式。通过PCR检测I类整合子及相关基因盒。
对氨苄青霉素（AP）、头孢哌酮（CPM）、头孢噻肟（CTX）、四环素（TM）、奈替米星（NI）、亚胺培南（IMI）、庆大霉素（AK）、环丙沙星（CIP）和庆大霉素（GM）抗菌药物的耐药率分别为100%、93.3%、33.3%、33.3%、30%、20%、20%、20%和13.3%。[细菌名称未给出]基因的分布结果显示，63.3%的分离株携带[细菌名称未给出]基因。此外，[其他基因名称未给出]基因的流行率估计分别为36.6%、33.3%、6.6%和0%。
我们的结果表明，I类整合子在[细菌名称未给出]分离株中广泛分布，并且与MDR分离株具有临床相关性。结果证实了持续监测以防止多重耐药性在伊朗[细菌名称未给出]菌株中传播的必要性。
