Upoyo Arif Setyo, Setyopranoto Ismail, Pangastuti Heny Suseani
Faculty of Health Sciences, Jenderal Soedirman University, Indonesia.
Doctoral Program of Nursing, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Indonesia.
Stroke Res Treat. 2021 Feb 24;2021:6683256. doi: 10.1155/2021/6683256. eCollection 2021.
This review aimed at figuring out the risk factors of uncontrolled hypertension in stroke.
This study systematically analyzed the hypertension risk factors available in the ProQuest, EBSCO, and PubMed databases published between 2010 and December 2019. The risk factors' pooled odds ratio (POR) included in this research was calculated using both fixed and random-effect models. The meta-data analysis was processed using the Review Manager 5.3 (Rev Man 5.3).
Of 1868 articles, seven studies were included in this review searched using specific keywords. Based on the analysis results, there were 7 risk factors of uncontrolled hypertension in stroke: medication nonadherence (POR = 2.23 [95% CI 1.71-2.89], = 0.342; = 6.7%), use of antihypertensive drugs (POR = 1.13 [95% CI 1.19-1.59, = 0.001; = 90.9%), stage of hypertension (POR = 1.14 [95% CI 1.02-1.27], = <0.001; = 97.1%), diabetes mellitus (POR = 0.71 [95% CI 0.52-0.99], = <0.001; = 96.5%), atrial fibrillation (POR = 1.74 [95% CI 1.48-2.04)], = <0.001; = 93.1%), triglycerides (POR = 1.47 [95% CI 1.23-1.75], = 0.879; = 0%), and age (POR = 1.03 [95% CI 0.89-1.18], = <0.001; = 97.5%]. There were no bias publications among studies. Medication nonadherence and triglycerides had homogeneous variations, while the others had heterogeneous variations.
Medication nonadherence, triglycerides, stage of hypertension, atrial fibrillation, and use of antihypertensive drugs significantly affect the uncontrolled hypertension in stroke.
本综述旨在找出卒中患者高血压控制不佳的危险因素。
本研究系统分析了2010年至2019年12月期间发表在ProQuest、EBSCO和PubMed数据库中的高血压危险因素。本研究纳入的危险因素合并比值比（POR）采用固定效应模型和随机效应模型计算。使用Review Manager 5.3（Rev Man 5.3）进行荟萃数据分析。
在1868篇文章中，通过使用特定关键词检索，本综述纳入了7项研究。根据分析结果，卒中患者高血压控制不佳有7个危险因素：用药依从性差（POR = 2.23 [95% CI 1.71 - 2.89]，P = 0.342；I² = 6.7%）、使用抗高血压药物（POR = 1.13 [95% CI 1.19 - 1.59]，P = 0.001；I² = 90.9%）、高血压分期（POR = 1.14 [95% CI 1.02 - 1.27]，P = <0.001；I² = 97.1%）、糖尿病（POR = 0.71 [95% CI 0.52 - 0.99]，P = <0.001；I² = 96.5%）、心房颤动（POR = 1.74 [95% CI 1.48 - 2.04]），P = <0.001；I² = 93.1%）、甘油三酯（POR = 1.47 [95% CI 1.23 - 1.75]，P = 0.879；I² = 0%）和年龄（POR = 1.03 [95% CI 0.89 - 1.18]，P = <0.001；I² = 97.5%]。研究之间无偏倚发表。用药依从性差和甘油三酯具有同质性变异，而其他因素具有异质性变异。
用药依从性差、甘油三酯、高血压分期、心房颤动和使用抗高血压药物显著影响卒中患者高血压控制不佳。
