Maffeis Giulia, Ferocino Edoardo, Mora Alberto Dalla, Pifferi Antonio, Cubeddu Rinaldo, Taroni Paola
Politecnico di Milano, Department of Physics, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
CNR-Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci, 32, 20133, Milan, Italy.
Biomed Opt Express. 2021 Jan 27;12(2):1105-1122. doi: 10.1364/BOE.412210. eCollection 2021 Feb 1.
A recent upgrade of the time domain multi-wavelength optical mammograph developed by Politecnico di Milano achieved good performance in laboratory tests [Biomed. Opt. Express9, 755 (2018).10.1364/BOE.9.000755]. However, it proved unsatisfactory when measurements were finally performed. That led to a further upgrade, including the replacement of the time-to-digital converter with a new model, and the related set-up changes. The new instrument version offers improved laboratory performance (as assessed through established protocols: BIP and MEDPHOT) and good performance (extension of the scanned breast area, repeatability, consistency of estimated tissue composition with physiology). Besides introducing the new set-up and detailing its laboratory and performance, we highlight the importance of systematic testing before entering clinical trials.
米兰理工大学开发的时域多波长光学乳腺成像仪最近进行了升级，在实验室测试中取得了良好的性能[《生物医学光学快报》9, 755 (2018).10.1364/BOE.9.000755]。然而，最终进行测量时却不尽人意。这导致了进一步的升级，包括用新型号替换时间数字转换器以及相关的设置更改。新的仪器版本在实验室性能方面有所提升（通过既定协议BIP和MEDPHOT评估），并且具有良好的性能（扩大了扫描乳腺区域、提高了重复性、估计的组织成分与生理学的一致性）。除了介绍新的设置并详细说明其实验室性能和临床性能外，我们还强调了在进入临床试验之前进行系统测试的重要性。
