Waks Serra M V, Noseda Grau V, Vera D A, Jodra S, García H A, Carbone N A, Pardini P A, Pomarico J A, Iriarte D I
CIFICEN (UNCPBA - CICPBA - CONICET), Pinto 399, 7000, Tandil, Argentina.
IFIMAT (UNCPBA), Pinto 399, 7000, Tandil, Argentina.
Heliyon. 2022 Aug 19;8(8):e10308. doi: 10.1016/j.heliyon.2022.e10308. eCollection 2022 Aug.
This work presents a method for constructing phantoms suitable for diffuse optical mammography. They are based on Polydimethylsiloxane silicones, with the characteristic of being anthropomorphic, and having similar mechanical and optical properties as a real breast. These phantoms are useful for testing the performance of diffuse optical imaging devices in the near infrared, both in transmittance and reflectance geometries, since they can be constructed containing inclusions, to simulate breast tumors. An alternative component to be used as scattering agent, that is easier to handle than traditional scattering agents, is also studied. The optical properties of the phantoms were tested varying the concentration of scattering and absorbing agents, while their mechanical properties were modified by adding a silicone fluid to the basic mixture. Finally, the phantoms were tested by Diffuse Optical Imaging experiments, and these images were compared to the ones obtained by conventional ultrasound techniques. Results show that the constructed anthropomorphic phantoms properly reproduce the optical and mechanical characteristics of human breasts, and are suitable to be used in Diffuse Optical Imaging.
这项工作提出了一种构建适用于漫射光乳腺成像的体模的方法。它们基于聚二甲基硅氧烷硅酮，具有拟人体特征，并且具有与真实乳房相似的机械和光学特性。这些体模可用于测试近红外漫射光成像设备在透射和反射几何构型下的性能，因为它们可以构建成包含内含物，以模拟乳腺肿瘤。还研究了一种比传统散射剂更易于处理的用作散射剂的替代成分。通过改变散射剂和吸收剂的浓度来测试体模的光学特性，同时通过向基础混合物中添加硅油来改变其机械性能。最后，通过漫射光成像实验对体模进行测试，并将这些图像与通过传统超声技术获得的图像进行比较。结果表明，构建的拟人体模能够恰当地再现人类乳房的光学和机械特性，并且适用于漫射光成像。
