Spinelli Lorenzo, Torricelli Alessandro, Pifferi Antonio, Taroni Paola, Danesini Gianmaria, Cubeddu Rinaldo
INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy.
Phys Med Biol. 2005 Jun 7;50(11):2489-502. doi: 10.1088/0031-9155/50/11/004. Epub 2005 May 18.
Characterization of both malignant and benign lesions in the female breast is presented as the result of a clinical study that involved more than 190 subjects in the framework of the OPTIMAMM European project. All the subjects underwent optical mammography, by means of a multi-wavelength time-resolved mammograph, in the range 637-985 nm. Optical images were processed by applying a perturbation model, relying on a nonlinear approximation of time-resolved transmittance curves in the presence of an inclusion, with the aim of estimating the major tissue constituents (i.e. oxy- and deoxy-haemoglobin, lipid and water) and structural parameters (linked to dimension and density of the scatterer centres) for both the lesion area and the surrounding tissue. The critical factors for the application of the perturbation model on in vivo data are also discussed. Forty-six malignant and 68 benign lesions were analysed. A subset of 32 cancers, 40 cysts and 14 fibroadenomas were found reliable for the perturbation analysis. For cancers, we show a higher blood content with respect to the surrounding tissue, while cysts are characterized by a lower concentration of scattering centres with respect to the surrounding tissue. For fibroadenomas, the low number of cases does not allow any definite conclusions.
作为一项临床研究的结果，本文展示了对女性乳房恶性和良性病变的特征描述。该临床研究是在欧洲OPTIMAMM项目框架内进行的，涉及190多名受试者。所有受试者均通过多波长时间分辨乳腺成像仪，在637 - 985 nm范围内接受了光学乳腺成像。通过应用一种微扰模型对光学图像进行处理，该模型依赖于在存在内含物的情况下对时间分辨透射率曲线的非线性近似，目的是估计病变区域和周围组织的主要组织成分（即氧合血红蛋白、脱氧血红蛋白、脂质和水）以及结构参数（与散射中心的尺寸和密度相关）。文中还讨论了将微扰模型应用于体内数据的关键因素。分析了46个恶性病变和68个良性病变。发现32例癌症、40个囊肿和14个纤维腺瘤的子集适用于微扰分析。对于癌症，我们发现其相对于周围组织具有更高的血液含量，而囊肿的特征是相对于周围组织具有更低浓度的散射中心。对于纤维腺瘤，由于病例数量较少，无法得出任何明确结论。
