Albert M L, Bachman D L, Morgan A, Helm-Estabrooks N
Department of Neurology, Boston University Medical School, MA.
Neurology. 1988 Jun;38(6):877-9. doi: 10.1212/wnl.38.6.877.
Selected features of aphasia may reflect disruption of specific neurotransmitter systems. Pharmacotherapy focused on these aphasic symptoms may improve language performance following stroke. We attempted to restore speech fluency in a patient with long-standing transcortical motor aphasia by treating his symptoms of hesitancy and impaired initiation of speech with bromocriptine. During therapy his language performance improved substantially, due to reduced latency of response, decreased paraphasias, and increased naming ability. After cessation of drug therapy his language returned to baseline.
失语症的某些特征可能反映特定神经递质系统的紊乱。针对这些失语症状的药物治疗可能会改善中风后的语言表现。我们试图通过用溴隐亭治疗一名长期患有经皮质运动性失语症患者的言语迟疑和言语起始受损症状来恢复其言语流畅性。在治疗期间，由于反应潜伏期缩短、言语错乱减少和命名能力提高，他的语言表现有了显著改善。停止药物治疗后，他的语言能力恢复到了基线水平。
