Sharma Aditi, Pant Kumud, Pande Akshara, Sinha Somya, Pant Bhasker
Deparment of Life Sciences, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India.
Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India.
Mater Today Proc. 2021;46:11169-11176. doi: 10.1016/j.matpr.2021.02.377. Epub 2021 Feb 27.
The havoc created by Corona virus has been dealt with using various integrative approaches adopted by laboratories through-out the world. Use of anti-viral peptides (AVPs) although new but has shown tremendous potential against many pathogens. Previously AVPs have been designed against spike protein of corona virus which is the major entry mediating molecule. Using various in-silico strategies, in this research work AVPs have been modeled against lesser studied viral proteins namely ORF7a protein, Envelope protein (E), Nucleoprotein (N), and Non-Structural protein (Nsp1 and Nsp2). The predicted AVPs have been docked against various host as well as viral proteins. The interaction of small AVPs seems capable of interfering with binding between viral protein and its host counterpart. Therefore, these AVPs can act as a deterrent against novel corona virus, which requires further validation through laboratory techniques.
世界各地的实验室采用了各种综合方法来应对新冠病毒造成的破坏。抗病毒肽（AVP）的使用虽然是新方法，但已显示出对许多病原体具有巨大潜力。以前曾针对新冠病毒的刺突蛋白设计过AVP，刺突蛋白是主要的进入介导分子。在这项研究工作中，利用各种计算机模拟策略，针对研究较少的病毒蛋白，即开放阅读框7a蛋白、包膜蛋白（E）、核蛋白（N）和非结构蛋白（Nsp1和Nsp2）对AVP进行了建模。预测的AVP已与各种宿主蛋白以及病毒蛋白进行对接。小型AVP的相互作用似乎能够干扰病毒蛋白与其宿主对应物之间的结合。因此，这些AVP可以作为对抗新型冠状病毒的一种威慑手段，这需要通过实验室技术进一步验证。
