Kalathil Dhanya, John Samu, Nair Asha S
Cancer Research Program-4, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.
Research Centre, University of Kerala, Thiruvananthapuram, India.
Front Oncol. 2021 Feb 15;10:626836. doi: 10.3389/fonc.2020.626836. eCollection 2020.
Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis, apoptosis, and redox signaling. In addition to being a boon for the normal functioning of a cell, FOXM1 turns out to be a bane by manifesting in several disease scenarios including cancer. It has been given an oncogenic status based on several evidences indicating its role in tumor development and progression. FOXM1 is highly expressed in several cancers and has also been implicated in poor prognosis. A comprehensive understanding of various aspects of this molecule has revealed its role in angiogenesis, invasion, migration, self- renewal and drug resistance. In this review, we attempt to understand various mechanisms underlying FOXM1 gene and protein regulation in cancer including the different signaling pathways, post-transcriptional and post-translational modifications. Identifying crucial molecules associated with these processes can aid in the development of potential pharmacological approaches to curb FOXM1 mediated tumorigenesis.
叉头框转录因子FOXM1参与多种细胞过程，如增殖、细胞周期进程、细胞分化、DNA损伤修复、组织稳态、血管生成、细胞凋亡和氧化还原信号传导。除了对细胞的正常功能有益外，FOXM1在包括癌症在内的多种疾病情况下也会成为祸根。基于多项表明其在肿瘤发生和发展中作用的证据，它已被赋予致癌地位。FOXM1在多种癌症中高表达，也与预后不良有关。对该分子各个方面的全面了解揭示了其在血管生成、侵袭、迁移、自我更新和耐药性中的作用。在本综述中，我们试图了解癌症中FOXM1基因和蛋白质调控的各种机制，包括不同的信号通路、转录后和翻译后修饰。识别与这些过程相关的关键分子有助于开发潜在的药理学方法来抑制FOXM1介导的肿瘤发生。
