Pensiero Stefano, Diplotti Laura, Visalli Gianluca, Ronfani Luca, Giangreco Manuela, Barbi Egidio
Department of Ophthalmology, Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, Italy.
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Front Pediatr. 2021 Feb 15;9:569262. doi: 10.3389/fped.2021.569262. eCollection 2021.
Congenital dacryostenosis is one of the most common ophthalmological disorders in infants, with a high spontaneous resolution rate. In patients unresponsive to conservative treatment, the first-line approach is lacrimal drainage system probing, thought there is no clear consensus on optimal timing of surgery. The optimal treatment of patients unresponsive to primary probing is also controversial. The aim of this study is to assess the optimal timing of probing in children with congenital dacryostenosis. Other purposes are to evaluate the efficacy of repeated probing and dacryointubation in patients unresponsive to the initial surgery without evident lacrimal outflow dysgenesis, and to determine the epidemiology of these maldevelopments. A retrospective consecutive cohort study was conducted in 625 eyes of 457 patients aged 7-48 months who underwent surgery for dacryostenosis. Patients were divided into 4 cohorts according to the timing of surgery. Data were analyzed using Fisher's test. The success rate of primary probing was high, without significant differences between cohorts. One-third of recurrences were related to maldevelopments, the other two-thirds were treated with a second probing or dacryointubation, with high success rates, that did not significantly differ between the procedures. All cases unresponsive to the second surgery were resolved with dacryointubation. Probing is highly effective and its outcome is not affected by timing of surgery. Nevertheless, we advocate for early intervention, in order to identify possible maldevelopments, which require more invasive management. In patients unresponsive to primary probing, without evident maldevelopments, repeated probing should still be considered as the first-line approach, since it's less invasive but similarly effective to dacryointubation.
先天性泪道狭窄是婴儿最常见的眼科疾病之一,自发缓解率高。对于保守治疗无反应的患者,一线治疗方法是泪道引流系统探查,不过对于最佳手术时机尚无明确共识。对初次探查无反应的患者的最佳治疗方法也存在争议。本研究的目的是评估先天性泪道狭窄患儿的最佳探查时机。其他目的是评估在初次手术无明显泪液流出发育异常但无反应的患者中重复探查和泪道插管的疗效,并确定这些发育异常的流行病学情况。对457例年龄在7至48个月因泪道狭窄接受手术的患者的625只眼进行了一项回顾性连续队列研究。根据手术时机将患者分为4组。数据采用Fisher检验进行分析。初次探查的成功率很高,各组之间无显著差异。三分之一的复发与发育异常有关,另外三分之二接受了二次探查或泪道插管治疗,成功率很高,两种治疗方法之间无显著差异。所有对二次手术无反应的病例均通过泪道插管治愈。探查非常有效,其结果不受手术时机的影响。然而,我们主张早期干预,以便识别可能需要更积极治疗的发育异常情况。对于初次探查无反应且无明显发育异常的患者,仍应将重复探查视为一线治疗方法,因为它侵入性较小,但与泪道插管效果相似。