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香精油对……的抗寄生虫活性

Anti-parasitic Activity of Essential Oil Against .

作者信息

Huang Si-Yang, Yao Na, He Jia-Kang, Pan Ming, Hou Zhao-Feng, Fan Yi-Min, Du Aifang, Tao Jian-Ping

机构信息

Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou, China.

出版信息

Front Cell Dev Biol. 2021 Feb 18;9:616340. doi: 10.3389/fcell.2021.616340. eCollection 2021.

DOI:10.3389/fcell.2021.616340
PMID:33681197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7930326/
Abstract

Toxoplasmosis is a global zoonotic disease, and one-third of the human population is chronically infected by . Due to the limited effectiveness and prominent side effects of the existing drugs, there is a dire need for the discovery of new therapeutic options in the treatment of toxoplasmosis. In this study, five essential oils (EO) were screened for their anti-parasitic activity against . The cytotoxicity of essential oils was evaluated using the MTT assay on human foreskin fibroblast cells. The CC values of EO, EO, EO, EO, and EO were found to be 22.74, 7.25, 15.01, 6.26, and 4.77 mg/mL, respectively. Only EO exhibited anti-parasitic activity, and inhibited the growth of in a dose-dependent manner. In addition, treatment with EO, was found to reduce the volume of tachyzoites and make their membrane surfaces rough. These results showed that EO was able to inhibit the growth of by reducing invasion, which may be due to its detrimental effect on the ability of tachyzoites to move. These findings suggest that EO could be a potential anti- drug, which may facilitate the development of new and effective treatments against toxoplasmosis.

摘要

弓形虫病是一种全球性人畜共患病，全球三分之一的人口受到其慢性感染。由于现有药物疗效有限且副作用显著，迫切需要发现治疗弓形虫病的新治疗方案。在本研究中，筛选了五种精油对[未提及具体寄生虫名称]的抗寄生虫活性。使用MTT法在人包皮成纤维细胞上评估了精油的细胞毒性。发现[未提及具体精油名称]1精油、[未提及具体精油名称]2精油、[未提及具体精油名称]3精油、[未提及具体精油名称]4精油和[未提及具体精油名称]5精油的CC值分别为22.74、7.25、15.01、6.26和4.77mg/mL。只有[未提及具体精油名称]4精油表现出抗寄生虫活性，并以剂量依赖的方式抑制[未提及具体寄生虫名称]的生长。此外，发现用[未提及具体精油名称]4精油处理可减少[未提及具体寄生虫名称]速殖子的体积并使其膜表面粗糙。这些结果表明，[未提及具体精油名称]4精油能够通过减少入侵来抑制[未提及具体寄生虫名称]的生长，这可能是由于其对速殖子运动能力的有害影响。这些发现表明，[未提及具体精油名称]4精油可能是一种潜在的抗[未提及具体寄生虫名称]药物，这可能有助于开发针对弓形虫病的新的有效治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/235b30280e4c/fcell-09-616340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/e4052019d656/fcell-09-616340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/b9d955263c0c/fcell-09-616340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/57a9e43e6cd9/fcell-09-616340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/17191c0445fc/fcell-09-616340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/235b30280e4c/fcell-09-616340-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/e4052019d656/fcell-09-616340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/b9d955263c0c/fcell-09-616340-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/57a9e43e6cd9/fcell-09-616340-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/17191c0445fc/fcell-09-616340-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e06/7930326/235b30280e4c/fcell-09-616340-g005.jpg

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