Lee Dong-Joon, Lee Seung-Jun, Lee Min-Jung, Kim Eun-Jung, Ohshima Hayato, Jung Han-Sung
Division in Anatomy and Developmental Biology, Department of Oral Biology, Taste Research Center, Oral Science Research Center, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
Division of Anatomy and Cell Biology of the Hard Tissue, Depart of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Biochem Biophys Rep. 2021 Feb 25;26:100945. doi: 10.1016/j.bbrep.2021.100945. eCollection 2021 Jul.
Tooth transplantation is one of the treatment options for extracted teeth that can be considered before dental implantation. Although the success rate of tooth transplantation is lower than that of implantation, tooth replantation and transplantation have the great advantage of using natural teeth. Tooth replantation might be considered a promising option in some cases. In present study, the expression patterns of revascularization and pulpal healing, which are the most important for the pulp viability, were analyzed after tooth replantation and allograft in mice. The inflammatory response and root dentin resorption were observed and not different between replantation and allograft in initiation of healing process. However, bonelike tissue formation, pulp revascularization and pulp healing were faster in replantation. The difference of healing patterns between tooth replantation and allograft found in present study will be helpful to select the treatment option and to understand healing mechanism.
牙齿移植是在牙种植之前可考虑的针对拔除牙齿的治疗选择之一。尽管牙齿移植的成功率低于种植，但牙齿再植和移植具有使用天然牙齿的巨大优势。在某些情况下，牙齿再植可能被视为一种有前景的选择。在本研究中，分析了小鼠牙齿再植和同种异体移植后对牙髓活力最为重要的血管再生和牙髓愈合的表达模式。观察了炎症反应和牙根牙本质吸收情况，在愈合过程开始时，再植和同种异体移植之间没有差异。然而，再植时骨样组织形成、牙髓血管再生和牙髓愈合更快。本研究中发现的牙齿再植和同种异体移植之间愈合模式的差异将有助于选择治疗方案并理解愈合机制。
