Ranjan Ratnesh, Verghese Shishir, Salian Romit, Manayath George J, Saravanan Veerappan R, Narendran Venkatapathy
Department of Retina and Vitreous Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu, India.
Am J Ophthalmol Case Rep. 2021 Feb 25;22:101042. doi: 10.1016/j.ajoc.2021.101042. eCollection 2021 Jun.
To describe the multimodal imaging findings and treatment outcomes in choroidal neovascularization secondary to Choroideremia.
A 13-year-old male presented with reduced visual acuity in the left eye. He gave a history of nyctalopia. His best-corrected visual acuity (BCVA) was 20/20 in the right eye and 20/40 in the left eye. Based on multimodal imaging, the diagnosis of choroideremia in both eyes with a subfoveal choroidal neovascularization in the left eye was made. He underwent five intravitreal anti-vascular endothelial growth factor (VEGF) injections of Ranibizumab over a period of 3 years, with the final injection given due to recurrence of neovascularization. Post-treatment, his BCVA improved to 20/20 in the left eye with regression of the neovascular network.
This case highlights the role of OCTA in diagnosis of choroidal neovascularization in choroideremia as well as its successful management with anti-VEGF injections with long term follow up.
描述继发于视网膜色素变性的脉络膜新生血管的多模态影像学表现及治疗效果。
一名13岁男性因左眼视力下降就诊。他有夜盲病史。其右眼最佳矫正视力（BCVA）为20/20，左眼为20/40。基于多模态影像学检查，诊断为双眼视网膜色素变性，左眼黄斑中心凹下脉络膜新生血管形成。在3年的时间里，他接受了5次玻璃体内注射雷珠单抗抗血管内皮生长因子（VEGF）治疗，最后一次注射是因为新生血管复发。治疗后，他左眼的BCVA提高到20/20，新生血管网络消退。
本病例强调了光学相干断层扫描血管造影（OCTA）在诊断视网膜色素变性相关脉络膜新生血管中的作用，以及抗VEGF注射联合长期随访对其成功治疗的效果。
