在巴西发现了一种古老的西尼罗河病毒株（NY99）的循环证据。
Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil.
机构信息
Universidade São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Clínica Médica, Ribeirão Preto, SP, Brasil.
Universidade São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular, Ribeirão Preto, SP, Brasil.
出版信息
Rev Soc Bras Med Trop. 2021 Mar 8;54. doi: 10.1590/0037-8682-0687-2020. eCollection 2021.
INTRODUCTION
In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease.
AIM
We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019.
METHODS
WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq.
RESULTS
Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005.
CONCLUSIONS
Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.
简介
2018 年，巴西首次在患有神经疾病的马匹中检测到西尼罗河病毒（WNV）。
目的
我们报告了首例来自塞阿拉州的马匹 WNV 感染病例，以及来自圣埃斯皮里图州的分离株的完整基因组序列。这两起感染均发生在 2019 年。
方法
从圣埃斯皮里图州一匹有神经症状的马的组织中分离出 WNV，并通过 MiSeq 进行测序。
结果
系统进化分析显示，该分离株属于 1a 谱系，与 NY99 株聚类，后者自 2005 年以来未在美国传播。
结论
我们的发现证实了 WNV 已在巴西多年来秘密传播的假说。
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