24R,25-二羟基维生素D3（一种调节钙代谢的内源性物质）的动物药理作用。

Animal pharmacological effects of 24R,25-dihydroxyvitamin D3 one of the endogenous substances regulating calcium metabolism.

作者信息

Maeda Y, Hirai T, Yamato H, Kobori N, Matsunaga K I, Oguchi Y, Yoshimura M, Fujii T, Kobayashi Y, Saitoh K I

机构信息

Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd, Tokyo, Japan.

出版信息

J Int Med Res. 1988 Mar-Apr;16(2):125-33. doi: 10.1177/030006058801600207.

DOI:10.1177/030006058801600207

PMID:3259937

Abstract

Lewis lung carcinoma was found to cause hypercalcaemia in tumour-bearing mice. 24R,25-Dihydroxyvitamin D3, a naturally occurring steric epimer, significantly prolonged the survival time of mice with Lewis lung carcinoma. It also had an analgesic effect in mice with Lewis lung carcinoma and increased the strength of bone weakened by the carcinoma which causes abnormal calcium metabolism and results in hypercalcaemia.

摘要

研究发现，Lewis肺癌可导致荷瘤小鼠出现高钙血症。24R,25-二羟维生素D3是一种天然存在的空间异构体，可显著延长Lewis肺癌小鼠的生存时间。它对Lewis肺癌小鼠还有镇痛作用，并增强了因癌症导致钙代谢异常和高钙血症而变弱的骨骼强度。