Faculty of Applied Sciences & Biotechnology, Shoolini university of Biotechnology & Management Sciences, Solan, India.
Centre for Translational Medicine, Lewis Katz School of Medicine, Medicine Education & Research Building, Temple University, Philadelphia, PA, USA.
Parasite Immunol. 2021 Jun;43(6):e12828. doi: 10.1111/pim.12828. Epub 2021 Mar 18.
Microsporidia are a group of obligate, intracellular, spore-forming eukaryotic pathogens, which predominantly infects immunocompromised individuals worldwide. Encephalitozoon spp. is one of the most prevalent microsporidia known to infect humans. Host immune system plays a major role in combating pathogens including Encephalitozoon spp. infecting humans. Both innate and adaptive arms of host immune system work together in combating Encephalitozoon infection. Researchers are conducting studies to elucidate the role of both arms of immune system against Encephalitozoon infection. In addition to cell-mediated adaptive immunity, role of innate immunity is also being highlighted in clearance of Encephalitozoon spp. from host body. Therefore, the current review will give a clear and consolidated update on the role of innate as well as adaptive immunity in protection against Encephalitozoon spp.
微孢子虫是一组专性、细胞内、孢子形成的真核病原体，主要感染全球免疫功能低下的个体。脑炎微孢子虫是已知感染人类的最常见的微孢子虫之一。宿主免疫系统在抵御包括脑炎微孢子虫在内的病原体方面起着重要作用。宿主免疫系统的先天和适应性免疫臂共同作用以抵御脑炎感染。研究人员正在进行研究，以阐明针对脑炎感染的免疫系统这两个臂的作用。除了细胞介导的适应性免疫外，先天免疫在清除宿主体内脑炎微孢子虫方面的作用也得到了强调。因此，本综述将对先天免疫和适应性免疫在抵御脑炎微孢子虫感染中的作用进行清晰和综合的更新。
