Mosqueira F G
Department of Chemistry, Universidad Nacional Autónoma de México, D.F.
Orig Life Evol Biosph. 1988;18(1-2):143-56. doi: 10.1007/BF01808788.
On the assumption of a uniform sample space probability hypothesis it is estimated a maximum number of polypeptides (or other kind of polymers) that could be synthesized in the prebiotic Earth. Besides, on the basis of five premises that are postulated as indispensable requirements for the origin of a living system, under the constraints of a protein-nucleic acid chemistry, it is concluded categorically that the origin of life event could not be the result of unbiased polymerization phenomena. On the contrary, biased and specific patterns of polymerization had to be an essential component in this fundamental event. Finally, several theories on the origin of life and complementary concepts like hypercyclic organization and self-organization phenomena in dissipative structures are discussed in the light of the conclusions arrived at in this work.
基于均匀样本空间概率假设,估算了在生命起源前的地球上可能合成的多肽(或其他类型聚合物)的最大数量。此外,基于作为生命系统起源不可或缺的要求而假定的五个前提,在蛋白质 - 核酸化学的限制下,明确得出生命起源事件不可能是无偏向聚合现象的结果。相反,有偏向和特定的聚合模式必定是这一基本事件的重要组成部分。最后,根据本研究得出的结论,讨论了几种关于生命起源的理论以及诸如超循环组织和耗散结构中的自组织现象等互补概念。