Department of Anatomy and Molecular Medicine, Alabama College of Osteopathic Medicine, Dothan, Alabama, USA.
Michigan Math and Science Academy, Warren, Michigan, USA.
Biochem Mol Biol Educ. 2021 May;49(3):441-445. doi: 10.1002/bmb.21497. Epub 2021 Mar 8.
Metabolomics is one of the newest areas in biochemistry dedicated to investigating small biomolecules in biofluids, tissues, and cells. Cutting edge instruments used in metabolomics studies make it possible to identify thousands of biomolecules and determine their interactions with biological networks. This tremendous area has increased the significance of accurate chemical nomenclature of compounds. Therefore, the classification of the organic molecules has become one of the most important issues in the field. Biogenic amines are nitrogenous compounds of low molecular weight formed by the decarboxylation of amino acids or by the amination and the transamination of aldehydes and ketones during normal metabolic processes. This letter covers the topic of nomenclature with respect to the current usage of biogenic amines in scientific literature. We use metabolomics as an example of field reporting data on trace levels of molecules that may be miscategorized in primary literature. We suggest that the incorrect classification of molecules will influence science education adversely because resources used for teaching are drawn from primary literature references that may contain errors.
代谢组学是生物化学中最新的领域之一，致力于研究生物体液、组织和细胞中的小分子生物分子。代谢组学研究中使用的尖端仪器使得能够鉴定数千种生物分子并确定它们与生物网络的相互作用。这个巨大的领域增加了化合物准确化学命名的重要性。因此，有机分子的分类已成为该领域最重要的问题之一。生物胺是由氨基酸脱羧或醛酮的胺化和转氨作用在正常代谢过程中形成的低分子量含氮化合物。这封信涵盖了生物胺在科学文献中的当前命名法使用的主题。我们以代谢组学为例，报告痕量分子的数据，这些分子在主要文献中可能被错误分类。我们认为，分子的不正确分类将对科学教育产生不利影响，因为用于教学的资源取自可能包含错误的主要文献参考文献。
