Isomura S
Aichi Prefectural Institute of Public Health, Nagoya, Japan.
Pediatr Infect Dis J. 1988 Apr;7(4):258-62. doi: 10.1097/00006454-198804000-00005.
A prominent increase of notified cases of pertussis was observed during discontinuation of pertussis immunization in Aichi Prefecture from 1975 to 1979. The patients were principally unimmunized children. After reintroduction of pertussis vaccine the number of cases decreased gradually and the decline has continued after the introduction of acellular pertussis vaccine. A retrospective survey of immunized schoolchildren also showed efficacy of the vaccine. To confirm the efficacy of acellular vaccine a prospective case contact study was conducted. Of 35 unimmunized children 29 developed clinically diagnosed pertussis, and of 52 children who received two or more doses of the vaccine only two developed disease after the household exposure. There were no serious systemic adverse reactions including high fever or encephalopathy. Severe local reaction occurred in 2.65/100,000 recipients of a third and fourth dose of the acellular vaccine.
1975年至1979年期间，爱知县停止百日咳免疫接种后，报告的百日咳病例显著增加。患者主要是未接种疫苗的儿童。重新引入百日咳疫苗后，病例数逐渐减少，在引入无细胞百日咳疫苗后，病例数持续下降。对已接种疫苗的学童进行的回顾性调查也显示了该疫苗的有效性。为了确认无细胞疫苗的有效性，进行了一项前瞻性病例对照研究。在35名未接种疫苗的儿童中，29名出现临床诊断的百日咳，在52名接种了两剂或更多剂疫苗的儿童中，只有两名在家庭接触后发病。没有出现包括高烧或脑病在内的严重全身不良反应。每10万名接种第三剂和第四剂无细胞疫苗的受种者中，严重局部反应的发生率为2.65。
