Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Department of Dermatology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Orbit. 2022 Aug;41(4):506-508. doi: 10.1080/01676830.2021.1893343. Epub 2021 Mar 7.
Many conditions present with periorbital edema and erythema, mimicking preseptal cellulitis. We report the unique case of a patient with relapsed monoblastic mutant isocitrate dehydrogenase-2 (IDH2) acute myeloid leukemia (AML) who presented with periorbital edema and erythema, unresponsive to antibiotics. Histopathology from punch biopsy was consistent with leukemia cutis. The patient responded rapidly to the initiation of enasidenib, a novel targeted inhibitor of mutant IDH2 enzymes. Our case highlights the importance of considering leukemia cutis in patients with a history of leukemia presenting with periorbital edema and erythema.
许多疾病都会出现眶周水肿和红斑，类似于眶隔蜂窝织炎。我们报告了一例复发性单核细胞白血病伴突变异柠檬酸脱氢酶 2（IDH2）的患者，其表现为眶周水肿和红斑，对抗生素治疗无反应。皮肤活检的组织病理学表现符合皮肤白血病。该患者对新型靶向突变 IDH2 酶抑制剂enasidenib 的治疗反应迅速。我们的病例强调了在有白血病病史的患者出现眶周水肿和红斑时，考虑皮肤白血病的重要性。
