Morgan K W, Callen J P
Department of Medicine, Division of Dermatology, University of Louisville, KY, USA.
J Am Acad Dermatol. 2001 Oct;45(4):590-5. doi: 10.1067/mjd.2001.119032.
Sweet's syndrome is characterized by the abrupt onset of fever, neutrophilic leukocytosis, and erythematous, tender pseudovesiculated plaques or nodules that respond readily to corticosteroid therapy. It is usually distinguished by the presence of mature neutrophils on histopathologic examination. We describe a 38-year-old man with acute myelogenous leukemia who had an erythematous vesicular eruption of the left eye develop that resembled cellulitis. A biopsy specimen revealed a dermal infiltrate of mature neutrophils and immature myeloblastic precursors. He later had hemorrhagic pseudovesiculated plaques develop bilaterally on his hands. A biopsy specimen again revealed abundant neutrophils with immature forms. A similar eruption developed at the site of a Hickman catheter placement 4 months later. His skin lesions responded rapidly to oral corticosteroids. This case is unique in that his initial presentation of Sweet's syndrome resembled orbital cellulitis that was characterized by immature myeloid precursors on histopathology.
斯威特综合征的特征为发热、中性粒细胞增多症突然发作，以及对皮质类固醇治疗反应迅速的红斑性、触痛性假水疱性斑块或结节。其通常通过组织病理学检查发现成熟中性粒细胞来加以鉴别。我们描述了一名38岁的急性髓系白血病男性患者，其左眼出现了类似蜂窝织炎的红斑性水疱疹。活检标本显示真皮内有成熟中性粒细胞和未成熟髓母细胞前体浸润。后来，他双手双侧出现了出血性假水疱性斑块。活检标本再次显示有大量未成熟形式的中性粒细胞。4个月后，在希克曼导管置入部位出现了类似皮疹。他的皮肤病变对口服皮质类固醇反应迅速。该病例的独特之处在于，其斯威特综合征的初始表现类似于眼眶蜂窝织炎，组织病理学特征为未成熟髓样前体。
