Department of Gastroenterology and endoscopy, Xiangyang No. 1 People's Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, China.
Department of Radiology, Xiangyang No. 1 People's Hospital Affiliated to Hubei University of Medicine, Xiangyang, Hubei 441000, China.
Technol Health Care. 2021;29(S1):153-164. doi: 10.3233/THC-218016.
The SARS-CoV-2 pneumonia infection is associated with high rates of hospitalization and mortality and this has placed healthcare systems under strain. Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value for timely treatment of severe NCP patients.
To summarize the clinical features and severe illness risk factors of the patients with novel coronavirus pneumonia (NCP), in order to provide support for the progression prediction, clinical treatment and prognosis of NCP patients.
A total of 196 NCP patients treated in our hospital from January 25, 2020 to June 21, 2020 were divided into the severe group and the mild group. The clinical features of the two groups were analyzed and compared. The risk factors were explored by using multivariate logistic regression, and the receiver operating characteristic (ROC) curve was obtained. The correlations of the risk factors with the prognosis of NCP were investigated combined with the lung function test.
The primary clinical symptoms of 196 cases of NCP included fever in 167 cases (85.2%) and cough in 121 cases (61.73%). The chest computed tomography (CT) scans of the 178 cases (90.81%) showed a typical ground-glass opacification. In 149 cases, the lymphocyte count was decreased, while the levels of creatine kinase (CK), lactate dehydrogenase (LDH), c-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and D-dimer (D-D) increased. 44 cases (22.45%) were found to be severely ill. The multivariate logistic regression analysis demonstrated that age, underlying disease, length of hospital stay, body mass index (BMI), LDH, chest CT visual score, absolute lymphocyte count (ALC) and CRP were risk factors for severe.
SARS-CoV-2 肺炎感染与高住院率和死亡率相关，这给医疗系统带来了压力。我们的研究为 NCP 的进展预测、临床治疗和预后提供了一种新方法，对及时治疗重症 NCP 患者具有重要的临床价值。
总结新型冠状病毒肺炎（NCP）患者的临床特征和重症发病危险因素，为 NCP 患者的进展预测、临床治疗和预后提供支持。
选取我院 2020 年 1 月 25 日至 6 月 21 日收治的 196 例 NCP 患者，分为重症组和轻症组，分析比较两组患者的临床特征。采用多因素 logistic 回归分析探讨危险因素，并绘制受试者工作特征（ROC）曲线。结合肺功能检查，探讨危险因素与 NCP 预后的相关性。
196 例 NCP 患者的主要临床症状包括发热 167 例（85.2%）、咳嗽 121 例（61.73%）。178 例（90.81%）患者的胸部 CT 扫描显示典型磨玻璃样混浊。149 例患者淋巴细胞计数减少，肌酸激酶（CK）、乳酸脱氢酶（LDH）、C 反应蛋白（CRP）、红细胞沉降率（ESR）和 D-二聚体（D-D）水平升高。44 例（22.45%）患者病情严重。多因素 logistic 回归分析表明，年龄、基础疾病、住院时间、体重指数（BMI）、LDH、胸部 CT 视觉评分、绝对淋巴细胞计数（ALC）和 CRP 是重症的危险因素。
