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建立个性化胎儿生长曲线模型。

Establishment of a personalized fetal growth curve model.

机构信息

Faculty of Environment and Life Sciences, Beijing University of Technology, Beijing 100124, China.

Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing 100124, China.

出版信息

Technol Health Care. 2021;29(S1):311-317. doi: 10.3233/THC-218028.

DOI:10.3233/THC-218028
PMID:33682767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8150511/
Abstract

BACKGROUND

Fetal weight is one of the important indicators for judging whether fetal growth and development are normal. Fetal weight exceeding the normal range may lead to poor delivery outcomes.

OBJECTIVE

We aimed to establish a personalized fetal growth curve in order to effectively monitor fetal growth during pregnancy. Fetal weight can be monitored while fetal growth and development are assessed.

METHODS

This study retrospectively analyzed the birth weight and ultrasound database of 3,093 newborns delivered at normal term. The personalized fetal growth curve model was generated based on the birth weight formula established by Gardosi combined with the proportional weight equation.

RESULTS

(1) The average birth weight of the single fetus at normal term was 3,457g. (2) According to the regression results of the proportion of fetal weight in full-term pregnancy and gestational week, the proportional weight equation is Weight% = 500.9 - 51.60GA + 1.727GA2- 0.01718GA3 (GA is gestational week), R2 is 98%, P< 0.001.

CONCLUSIONS

In this study, the normal birth weight of newborns and normal range of fetal weight can be estimated by using the personalized fetal growth curve model.

摘要

背景

胎儿体重是判断胎儿生长发育是否正常的重要指标之一。胎儿体重超出正常范围可能导致不良分娩结局。

目的

建立个性化胎儿生长曲线,以便在妊娠期间有效监测胎儿生长情况。同时可以监测胎儿生长发育情况,监测胎儿体重。

方法

本研究回顾性分析了 3093 例足月分娩新生儿的出生体重和超声数据库。基于 Gardosi 建立的出生体重公式,结合比例体重方程,生成个性化胎儿生长曲线模型。

结果

(1)足月单胎胎儿的平均出生体重为 3457g。(2)根据胎儿体重占足月妊娠和孕周比例的回归结果,比例体重方程为 Weight%=500.9-51.60GA+1.727GA2-0.01718GA3(GA 为孕周),R2 为 98%,P<0.001。

结论

本研究通过使用个性化胎儿生长曲线模型,可以估计新生儿的正常出生体重和胎儿体重的正常范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8558/8150511/431353f52db7/thc-29-thc218028-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8558/8150511/226fbb73bacd/thc-29-thc218028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8558/8150511/431353f52db7/thc-29-thc218028-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8558/8150511/226fbb73bacd/thc-29-thc218028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8558/8150511/431353f52db7/thc-29-thc218028-g002.jpg

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本文引用的文献

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Comparison of estimated fetal weight percentiles near term for predicting extremes of birthweight percentile.比较足月时估计胎儿体重百分位数以预测出生体重百分位数的极值。
Am J Obstet Gynecol. 2021 Mar;224(3):292.e1-292.e19. doi: 10.1016/j.ajog.2020.08.054. Epub 2020 Aug 21.
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A new customized fetal growth standard for African American women: the PRB/NICHD Detroit study.一项针对非裔美国女性的新定制胎儿生长标准:PRB/NICHD 底特律研究。
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INTERGROWTH-21 胎儿生长标准:迈向全球妊娠和儿科保健一体化。
Am J Obstet Gynecol. 2018 Feb;218(2S):S630-S640. doi: 10.1016/j.ajog.2018.01.011.
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The effect of customization and use of a fetal growth standard on the association between birthweight percentile and adverse perinatal outcome.定制和使用胎儿生长标准对出生体重百分位与不良围产结局之间的关系的影响。
Am J Obstet Gynecol. 2018 Feb;218(2S):S738-S744. doi: 10.1016/j.ajog.2017.11.563. Epub 2017 Dec 2.
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Prospective assessment of INTERGROWTH-21 and World Health Organization estimated fetal weight reference curves.前瞻性评估 INTERGROWTH-21 和世界卫生组织估计胎儿体重参考曲线。
Ultrasound Obstet Gynecol. 2018 Jun;51(6):792-798. doi: 10.1002/uog.17514.
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International estimated fetal weight standards of the INTERGROWTH-21 Project.INTERGROWTH-21项目的国际胎儿体重估计标准。
Ultrasound Obstet Gynecol. 2017 Apr;49(4):478-486. doi: 10.1002/uog.17347. Epub 2017 Mar 5.
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INTERGROWTH-21st vs customized birthweight standards for identification of perinatal mortality and morbidity.INTERGROWTH-21st标准与定制出生体重标准用于围产期死亡率和发病率的识别比较
Am J Obstet Gynecol. 2016 Apr;214(4):509.e1-509.e7. doi: 10.1016/j.ajog.2015.10.931. Epub 2015 Nov 4.
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