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不明原因的 COVID-19!病理尸检是否是灵丹妙药?

Inexplicable COVID-19! Would pathological autopsy be the panacea?

机构信息

Department of Forensic Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.

Department of Forensic Medicine, All India Institute of Medical Sciences, Jodhpur, India..

出版信息

Acta Biomed. 2021 Mar 2;92(1):e2021175. doi: 10.23750/abm.v92i1.11019.

DOI:10.23750/abm.v92i1.11019
PMID:33682800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7975940/
Abstract

SARS-CoV-2 has swamped the entire world, unfolding into a COVID-19 pandemic. Efforts are on to develop an understanding of the various aspects related to SARS-CoV-2 and COVID-19. A pathological autopsy can play a vital role in understanding the pathophysiology of the disease, which may be vital in evolving effective management strategies. Despite its significance in the present circumstances, only a limited number of pathological autopsies are being conducted worldwide. The paper stresses on the need for taking up pathological autopsies globally and discusses its present status and the way forward, along with international perspectives and recommendations for consideration of pathological autopsy.

摘要

SARS-CoV-2 肆虐全球,引发了 COVID-19 大流行。目前正在努力了解与 SARS-CoV-2 和 COVID-19 相关的各个方面。病理尸检可以在理解疾病的病理生理学方面发挥重要作用,这对于制定有效的管理策略可能至关重要。尽管在当前情况下具有重要意义,但全球范围内进行的病理尸检数量有限。本文强调了在全球范围内进行病理尸检的必要性,并讨论了其现状和未来发展方向,以及国际观点和建议,以供病理尸检考虑。

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本文引用的文献

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A roadmap to the safe practice of forensic medicine in the COVID-19 pandemic.COVID-19大流行期间法医学安全实践路线图。
J Forensic Leg Med. 2020 Nov;76:102036. doi: 10.1016/j.jflm.2020.102036. Epub 2020 Oct 15.
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Inside the lungs of COVID-19 disease.在 COVID-19 疾病的肺部内部。
Int J Legal Med. 2020 Jul;134(4):1271-1274. doi: 10.1007/s00414-020-02318-9. Epub 2020 May 26.
3
No Autopsies on COVID-19 Deaths: A Missed Opportunity and the Lockdown of Science.未对新冠死亡病例进行尸检:错失的机会与科学的封锁
J Clin Med. 2020 May 14;9(5):1472. doi: 10.3390/jcm9051472.
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Autopsy slowdown hinders quest to determine how coronavirus kills.尸检工作放缓阻碍了确定新冠病毒致死方式的探索。
Nature. 2020 May 7. doi: 10.1038/d41586-020-01355-z.
5
Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.对新冠病毒疾病(COVID-19)患者的尸检显示,肺部出现弥漫性肺泡损伤,伴有严重的毛细血管充血,肺部及其他器官呈现出多样化的表现,提示存在血管功能障碍。
Histopathology. 2020 Aug;77(2):198-209. doi: 10.1111/his.14134. Epub 2020 Jul 5.
6
COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy!新冠死亡病例:我们确定是肺炎吗?拜托,进行尸检,尸检,尸检!
J Clin Med. 2020 Apr 26;9(5):1259. doi: 10.3390/jcm9051259.
7
The autopsy debate during the COVID-19 emergency: the Italian experience.新冠疫情期间的尸检辩论:意大利的经验
Virchows Arch. 2020 Jun;476(6):821-823. doi: 10.1007/s00428-020-02828-2.
8
Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China.中国 26 例 COVID-19 死亡患者的肾脏组织病理分析。
Kidney Int. 2020 Jul;98(1):219-227. doi: 10.1016/j.kint.2020.04.003. Epub 2020 Apr 9.
9
Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies.通过尸体核心活检对 2019 年新型冠状病毒病(COVID-19)的病理学研究。
Mod Pathol. 2020 Jun;33(6):1007-1014. doi: 10.1038/s41379-020-0536-x. Epub 2020 Apr 14.
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COVID-19 Autopsies, Oklahoma, USA.美国俄克拉荷马州的 COVID-19 尸检。
Am J Clin Pathol. 2020 May 5;153(6):725-733. doi: 10.1093/ajcp/aqaa062.